M0639

6α-Methylprednisolone

synthetic, ≥98%, glucocorticoid, powder

• Synonyme(s) : 11β,17α,21-trihydroxy-6α-méthyl-1,4-pregnadiène-3,20-dione, 6α-méthyl-11β,17α,21-trihydroxy-1,4-pregnadiène-3,20-dione
• Formule empirique (notation de Hill) : C₂₂H₃₀O₅
• Numéro CAS: 83-43-2
• Poids moléculaire : 374.47
• NACRES: NA.77
• PubChem Substance ID: 24896564
• UNSPSC Code: 12352200
• EC Number: 201-476-4
• MDL number: MFCD00010591
• Beilstein/REAXYS Number: 2340300
• Assay: ≥98%
• Form: powder

Propriétés

• Nom du produit: 6α-Methylprednisolone, ≥98%
• biological source: synthetic
• Quality Segment: 200
• sterility: non-sterile
• assay: ≥98%
• form: powder
• solubility: chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow
• application(s): cell analysis
• shipped in: ambient
• storage temp.: room temp
• SMILES string: [H][C@@]12C[C@H](C)C3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
• InChI: 1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1
• InChI key: VHRSUDSXCMQTMA-PJHHCJLFSA-N
• Gene Information: human ... NR3C1(2908) ; rat ... Nr3c1(24413)

Description

Application

6α-Methylprednisolone has been used:

• to stimulate RPMI 8226.1 cells in order to govern the expression of human interleukin-10 (IL-10) gene
• to induce depletion of CD14⁺ CD16⁺ monocytes
• to study its effect on behavioral and sensory afferent hypersensitivity

Biochem/physiol Actions

Methylprednisolone is a glucocorticoid having anti-inflammatory and immunosuppressive actions. It is useful in treating skin diseases, allergies, multiple sclerosis, asthma, rheumatic disorders, chronic obstructive pulmonary disease, croup and cancer.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mot-clé: Danger
• Codes de danger: H360FD,H373
• Mentions de précaution: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B - STOT RE 2
• Organes cibles: Adrenal gland,Immune system
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Que se passe-t-il ?: WGK 2
• EPI (équipement de protection individuelle): Eyeshields, Gloves, type N95 (US)