L9756

(−)-Tetramisole hydrochloride

powder, ≥99% (GC)

• Synonyme(s) : (S)-(−)-6-phényl-2,3,5,6-tétrahydroimidazo[2,1-b]thiazole hydrochloride, L(−)-2,3,5,6-tétrahydro-6-phénylimidazo(2,1-b)thiazole hydrochloride
• Formule empirique (notation de Hill) : C₁₁H₁₂N₂S · HCl
• Numéro CAS: 16595-80-5
• Poids moléculaire : 240.75
• NACRES: NA.77
• PubChem Substance ID: 24278526
• UNSPSC Code: 12352202
• EC Number: 240-654-6
• MDL number: MFCD00012675
• Beilstein/REAXYS Number: 4358988

Propriétés

• Nom du produit: (−)-Tetramisole hydrochloride, ≥99% (GC)
• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥99% (GC)
• form: powder
• mp: 228-230 °C
• solubility: water: 50 mg/mL, clear, colorless to faintly yellow
• antibiotic activity spectrum: parasites
• mode of action: enzyme | inhibits
• SMILES string: Cl.C1CN2C[C@@H](N=C2S1)c3ccccc3
• InChI: 1S/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H/t10-;/m1./s1
• InChI key: LAZPBGZRMVRFKY-HNCPQSOCSA-N

Description

Application

Suitable for inhibition of various mammalian alkaline phosphatase (i.e., liver, kidney, placenta, bone and tumor).
Intestinal alkaline phosphatases are only slightly inhibited.
Not for veterinary use.

Biochem/physiol Actions

Shows both immunostimulant and immunosuppressant effects, depending on several controllable factors. Very effective in treatment of ascariasis (hookworm infestation). Useful in chemotherapy of colorectal cancers, possibly due to its stimulation of IL-1 production and direct activation of macrophages.

Other Notes

Levamisole hydrochloride is soluble in water at 50mg/mL yielding a clear, colorless solution. Solutions are stable at 2-8°C for ~1 month.

Informations sur la sécurité

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P301 + P310 + P330
• Hazard Classifications: Acute Tox. 3 Oral
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges