L4129

L-α-Lysophosphatidylcholine from egg yolk

≥99%, Type I, powder

• Synonyme(s) : 1-Acyl-sn-glycero-3-phosphocholine, L-α-Lysolecithin
• Numéro CAS: 9008-30-4
• UNSPSC Code: 12352211
• EC Number: 232-715-0
• NACRES: NA.25
• MDL number: MFCD00131444

Propriétés

• biological source: egg yolk
• Quality Segment: 200
• description: zwitterionic
• type: Type I
• assay: ≥99%
• form: powder
• color: white
• functional group: phospholipid
• lipid type: phosphoglycerides
• shipped in: ambient
• storage temp.: −20°C

Description

Application

L-α-Lysophosphatidylcholine from egg yolk has been used:

• as a surfactant
• as a media supplement and in Staphylococcus aureus inhibition assay in dermatitis
• as a demyelinating agent for nerve
• as a component in sperm nuclei preparation buffer

Biochem/physiol Actions

Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis. It is used to demyelinate spinal neurons and study the processes underlying remyelination. It activates protein kinase C, p38 MAP kinase, p42 MAP Kinase, and the jun kinase (JNK) pathway, and stimulates transcription of c-jun.

Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis. It is used to demyelinate spinal neurons and study the processes underlying remyelination. It activates protein kinase C, p38 MAP kinase, p42 MAP Kinase, and the jun kinase (JNK) pathway, and stimulates transcription of c-jun. Lysophosphatidylcholine accumulates during cardiac ischemia and may induce arrhythmias by uncoupling gap junction communication, and increase ischemic damage by enhancing Na⁺ loading in cardiac myocytes. It also activates TREK1, TREK2 and TRAAK K⁺ channels.

Preparation Note

Prepared by the action of phospholipase A on egg L-α-phosphatidylcholine.

Analysis Note

Contains primarily palmitic and stearic acids.

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)