K1140

Kifunensine

solid,film or powder, ≥98%

• Synonyme(s) : FR 900494, Hexahydro-6R,7S,8aS-trihydroxy-5R-(hydroxymethyl)-imidazo[1,2-a] pyridine-2,3-dione
• Formule empirique (notation de Hill) : C₈H₁₂N₂O₆
• Numéro CAS: 109944-15-2
• Poids moléculaire : 232.19
• UNSPSC Code: 12352204
• NACRES: NA.77

Propriétés

• Nom du produit: Kifunensine, mannosidase inhibitor
• biological source: synthetic (organic)
• Quality Segment: 100
• assay: ≥98%
• form: film or powder, solid
• solubility: water, double-distilled: 50 mM
• storage temp.: −20°C
• SMILES string: N21[C@H](NC(=O)C2=O)[C@H]([C@H]([C@@H]([C@H]1CO)O)O)O
• InChI: 1S/C8H12N2O6/c11-1-2-3(12)4(13)5(14)6-9-7(15)8(16)10(2)6/h2-6,11-14H,1H2,(H,9,15)/t2-,3-,4+,5+,6+/m1/s1
• InChI key: OIURYJWYVIAOCW-PQMKYFCFSA-N
• Gene Information: human ... MAN1A1(4121), MAN1A2(10905), MAN1B1(11253), MAN1C1(57134) ; mouse ... MAN1A1(17155), MAN1A2(17156), MAN1B1(227619), MAN1C1(230815) ; rat ... MAN1A1(294410), MAN1A2(295319), MAN1B1(499751), MAN1C1(362625)

Description

General description

Kifunensine is an alkaloid compound, isolated from the actinomycete Kitasporia kifunensis.

Application

Kifunensine has been used as an inhibitor of mannosidase I in Jurkat T-cells, human embryonic kidney (HEK293T/17) cells and in mouse embryonic fibroblast cells.

Biochem/physiol Actions

Kifunensine is a selective inhibitor of class I glycoprotein-processing α-mannosidases.

Kifunensine suppresses endoplasmic reticulum-associated degradation (ERAD) via the inhibition of endoplasmic reticulum-associated mannosidase activity. It is also a glycosidase inhibitor for Class I CAZy glycosylhydrolase family 47.

Informations sur la sécurité

• pictograms: GHS07
• signalword: Warning
• hcodes: H319
• pcodes: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)