I1637

Ipratropium bromide monohydrate

≥98% (TLC), powder

• Synonyme(s) : Atropine isopropyl bromide
• Formule empirique (notation de Hill) : C₂₀H₃₀BrNO₃ · H₂O
• Numéro CAS: 66985-17-9
• Poids moléculaire : 430.38
• NACRES: NA.77
• PubChem Substance ID: 24277843
• UNSPSC Code: 12352200
• EC Number: 244-873-8
• MDL number: MFCD00792907
• Assay: ≥98% (TLC)
• Form: powder

Propriétés

• Quality Segment: 200
• assay: ≥98% (TLC)
• form: powder
• color: white
• solubility: H₂O: 10 mg/mL
• originator: Boehringer Ingelheim
• SMILES string: O.[Br-].CC(C)[N@+]1(C)[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3
• InChI: 1S/C20H30NO3.BrH.H2O/c1-14(2)21(3)16-9-10-17(21)12-18(11-16)24-20(23)19(13-22)15-7-5-4-6-8-15;;/h4-8,14,16-19,22H,9-13H2,1-3H3;1H;1H2/q+1;;/p-1/t16-,17+,18+,19?,21?;;
• InChI key: KEWHKYJURDBRMN-XSAPEOHZSA-M
• Gene Information: human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)

Description

Application

Ipratropium bromide monohydrate has been used for the inhibition of peripheral muscarinic receptors in rats.

Biochem/physiol Actions

Ipratropium bromide monohydrate is a nonselective muscarinic acetylcholine receptor antagonist and a bronchodilator. In nebulized form, it is used for treating asthma and obstructive pulmonary diseases. It acts as a β₂ adrenoreceptor agonist. Ipratropium bromide monohydrate is an anticholinergic agent and competes with acetylcholine. It promotes bronchodilation by stimulating sympathetic pathways.

Features and Benefits

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

N-isopropyl quaternary salt of atropine.

Informations sur la sécurité

• pictograms: GHS07
• signalword: Warning
• hcodes: H302 + H332,H319
• pcodes: P261 - P264 - P271 - P301 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2
• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 2