H6166

Interferon α 2B human

HumanKine^®, ≥95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized powder, suitable for cell culture

• Synonyme(s) : IFN α 2B, IFN Alfa 2b, INF α 2B, INF Alfa 2b, Interferon Alfa 2b
• Numéro MDL: MFCD01773210
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.77

Propriétés

• product name: Interferon α 2B human, IFN-α 2B, recombinant, expressed in HEK 293 cells, HumanKine^®, suitable for cell culture
• Source biologique: human
• Niveau de qualité: 100
• Produit recombinant: expressed in HEK 293 cells
• Pureté: ≥95% (SDS-PAGE)
• Forme: lyophilized powder
• Puissance: ≤0.12 ng/mL EC₅₀
• Qualité: endotoxin tested
• Poids mol.: dimer 16 kDa (glycosylated)
• Conditionnement: poly bottle of 10 μg (in poly bottle)
• Fabricant/nom de marque: HumanZyme
• Technique(s): cell culture | mammalian: suitable
• Impuretés: ≤1EU/mg
• Numéro d'accès UniProt: P01563
• Température de stockage: −20°C
• Informations sur le gène: human ... IFNA2(3440)

Description

Description générale

The interferon α 2 (IFN-α2) exists in three forms 2a, 2b and 2c. It consists of 165 amino acids and five α helices. IFN-α2B is found structurally stable at pH 7. The recombinant IFN-α is nonglycosylated compared to the natural human IFN-α.

Actions biochimiques/physiologiques

Interferon α 2B (IFN-α 2B) belongs to the type I interferon protein family. It is produced by many cell types in response to viral infection. IFN-α 2B has antiproliferative and antitumor activities, as well as induction of apoptosis and the inflammatory response. It enhances the expression of MHC proteins by increasing the presentation of antigen peptides and activates cytotoxic T-cells.

Forme physique

Lyophilized from a 0.2 μm filtered solution of 1x PBS.

Notes préparatoires

HumanKine IFN-α 2B is a glycosylated monomer expressed in HEK 293 cells with an apparent molecular mass of 16 kDa. Production in human 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.

Remarque sur l'analyse

The specific activity was determined by the dose-dependent proliferation of WISH (heteroploid human amnion cell line) in presence of VSV ( vesicular stomatitis virus).

Informations légales

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable