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H1635

Sigma-Aldrich

N-Hippuryl-His-Leu hydrate

chromogenic, ≥98% (HPLC), powder

Synonyme(s) :

N-Benzoyl-Gly-His-Leu, N-Hippuryl-L-histidyl-L-leucine hydrate

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About This Item

Formule empirique (notation de Hill):
C21H27N5O5 · xH2O
Numéro CAS:
207386-83-2
Poids moléculaire :
429.47 (anhydrous basis)
Numéro Beilstein :
5664178
Numéro CE :
250-597-9
Numéro MDL:
MFCD00149318
Code UNSPSC :
12352204
ID de substance PubChem :
24895469
Nomenclature NACRES :
NA.32

product name

N-Hippuryl-His-Leu hydrate, powder, ≥98% (HPLC)

Pureté

≥98% (HPLC)

Forme

powder

Couleur

white to off-white

Solubilité

acetic acid: ~50 mg/mL

Température de stockage

−20°C

Chaîne SMILES 

O.CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)c2ccccc2)C(O)=O

InChI

1S/C21H27N5O5.H2O/c1-13(2)8-17(21(30)31)26-20(29)16(9-15-10-22-12-24-15)25-18(27)11-23-19(28)14-6-4-3-5-7-14;/h3-7,10,12-13,16-17H,8-9,11H2,1-2H3,(H,22,24)(H,23,28)(H,25,27)(H,26,29)(H,30,31);1H2/t16-,17-;/m0./s1

Clé InChI

NWOJMNXIJBZMPK-QJHJCNPRSA-N

Informations sur le gène

human ... ACE(1636) , ACE2(59272)
mouse ... ACE3(217246)
rat ... ACE(11421) , ACE2(70008) , ACE3(498012)

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Amino Acid Sequence

NBz-Gly-His-Leu

Application

N-Hippuryl-His-Leu hydrate has been used in the measurement of angiotensin-converting enzyme (ACE) inhibitory activity using oyster hydrolysates, semimembranosus muscle samples, and rabbit lung acetone powder.

Actions biochimiques/physiologiques

N-Hippuryl-His-Leu hydrate (HHL) can be used as an artificial substrate for angiotensin-converting enzyme (ACE).

Substrats

Substrate for angiotensin converting enzyme.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

In Silico Elucidation of the Molecular Recognition of Phenol Derivative Compounds and Hippuryl-histidyl-leucine as an Artificial Substrate with the Experimental Target: Angiotensin-converting Enzyme
Vazquez-Valaldez VH, et al.
Letters in Drug Design & Discovery (2020)
A Tiengo et al.
Journal of food science, 74(5), H121-H126 (2009-08-04)
Amaranth seeds have been considered as an excellent alternative or complementary source of food protein due to their balanced amino acid composition. However, their potential as a source of bioactive peptides has not been explored. The present study is aimed
Flávia Giacometti Cavalheiro et al.
Food chemistry, 333, 127482-127482 (2020-07-14)
In order to evaluate differences in the peptide profile and bioactive potential in dairy products, by increasing the protein content and using proteolytic bacteria strain to enable the release of bioactive peptides, a high-protein yogurt with adjunct culture was developed.
Ida-Johanne Jensen et al.
Meat science, 96(2 Pt A), 916-921 (2013-11-12)
The aims of this study were to evaluate and compare proximate composition, antihypertensive activity and antioxidative capacity of the semimembranosus muscle from pork and beef and to study how these characteristics were affected by household preparation and subsequent digestion. The
Darcy R Flora et al.
Endocrinology, 151(6), 2769-2776 (2010-04-13)
Natriuretic peptide receptor-A (NPR-A), also known as guanylyl cyclase-A, is a transmembrane receptor guanylyl cyclase that is activated by the cardiac hormones atrial natriuretic peptide and B-type natriuretic peptide. Although ligand-dependent NPR-A degradation (also known as down-regulation) is widely acknowledged
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