F8929

Fluconazole

≥98% (HPLC), powder, fungal cytochrome P-450 sterol C-14 α-demethyllation inhibitor

• Synonyme(s) : 2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
• Formule empirique (notation de Hill) : C₁₃H₁₂F₂N₆O
• Numéro CAS: 86386-73-4
• Poids moléculaire : 306.27
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724485
• NACRES: NA.77
• MDL number: MFCD00274549
• Assay: ≥98% (HPLC)
• Form: powder

Propriétés

• Nom du produit: Fluconazole, ≥98% (HPLC), powder
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• solubility: DMSO: 5 mg/mL
• antibiotic activity spectrum: fungi
• mode of action: enzyme | inhibits
• storage temp.: room temp
• SMILES string: FC1=CC(F)=C(C(CN2N=CN=C2)(O)CN3N=CN=C3)C=C1
• InChI: 1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2
• InChI key: RFHAOTPXVQNOHP-UHFFFAOYSA-N
• Gene Information: human ... CYP1A2(1544)

Description

General description

Fluconazole is used to treat adult neutropenic patients with invasive candidiasis (IC).

Application

Fluconazole has been used to assess minimum inhibitory concentration (MIC)-fungal assay. It has also been used as a positive control in antifungal assay of plants.

Biochem/physiol Actions

Fluconazole is an antifungal agent. It is highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethyllation. Fluconazole is a potent inhibitor of CYP2C9. Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene.

Fluconazole is an antifungal agent; highly selctive inhibitor of fungal cytochrome P-450 sterol C-14 α-demethyllation. Potent inhibitor of CYP2C9. Interferes with fungal ergosterol synthesis; downregulates metallothionein gene.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Informations sur la sécurité

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302,H360D,H362,H412
• pcodes: P202 - P260 - P263 - P273 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 3 - Lact. - Repr. 1B
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves