F1293

Finasteride

≥98% (HPLC), Selective 5α-reductase inhibitor, powder

• Synonyme(s) : N-(2-methyl-2-propyl)-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide, N-tert-Butyl-3-oxo-4-aza-5α-androst-1-en-17β-carboxamide, MK-906
• Formule empirique (notation de Hill) : C₂₃H₃₆N₂O₂
• Numéro CAS: 98319-26-7
• Poids moléculaire : 372.54
• UNSPSC Code: 41116107
• PubChem Substance ID: 24724479
• NACRES: NA.77
• MDL number: MFCD00869737
• Assay: ≥98% (HPLC)
• Form: powder

Propriétés

• Nom du produit: Finasteride, ≥98% (HPLC), powder
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: soluble >20 mg/mL
• storage temp.: room temp
• SMILES string: [H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](C(=O)NC(C)(C)C)[C@@]4(C)CC[C@]3([H])[C@@]1(C)C=CC(=O)N2
• InChI: 1S/C23H36N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h11,13-18H,6-10,12H2,1-5H3,(H,24,26)(H,25,27)/t14-,15-,16-,17+,18+,22-,23+/m0/s1
• InChI key: DBEPLOCGEIEOCV-WSBQPABSSA-N
• Gene Information: human ... HSD3B1(3283), SRD5A1(6715), SRD5A2(6716) ; rat ... Hsd3b1(360348), Srd5a1(24950), Srd5a2(64677)

Description

Application

Finasteride has been used:

• as a component of L-15 media to investigate the effects of finasteride exposure on brain, liver and testis tissues
• in culture medium to treat tumor cells in vitro
• as a positive control to treat benign prostatic hyperplasia (BPH)
• to examine its effect on structural and molecular biology on the ventral prostate of senile mice

Biochem/physiol Actions

Finasteride can reduce serum and scalp dihydrotestosterone (DHT) by preventing the transformation of testosterone to DHT. It is usually used to manage benign prostate hyperplasia and pattern hair loss in male. Finasteride possesses androgen-distracting properties.

Selective 5α-reductase inhibitor; antiandrogen.

Informations sur la sécurité

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302,H360FD
• pcodes: P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 1B
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves