D7000

Deoxycorticosterone acetate

synthetic (organic), ≥98% (HPLC), mineralocorticoid and glucocorticoid, powder

• Synonyme(s) : 21-hydroxy-4-pregnène-3,20-dione 21-acétate, 4-Pregnène-21-ol-3,20-dione 21-acétate, Cortexone acétate, DOC acétate
• Formule empirique (notation de Hill) : C₂₃H₃₂O₄
• Numéro CAS: 56-47-3
• Poids moléculaire : 372.50
• NACRES: NA.77
• PubChem Substance ID: 24894065
• UNSPSC Code: 12352200
• EC Number: 200-275-9
• MDL number: MFCD00003660
• Beilstein/REAXYS Number: 2570798
• Assay: ≥98% (HPLC)
• Form: powder

Propriétés

• Nom du produit: Deoxycorticosterone acetate,
• biological source: synthetic (organic)
• Quality Segment: 200
• sterility: non-sterile
• assay: ≥98% (HPLC)
• form: powder
• solubility: H₂O: insoluble, acetone: soluble (1 in 30), alcohol: soluble (1 in 50), chloroform: freely soluble, dioxane: slightly soluble, vegetable oils: slightly soluble
• shipped in: ambient
• storage temp.: room temp
• SMILES string: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@]([H])(CC[C@@]24[H])C(=O)COC(C)=O
• InChI: 1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1
• InChI key: VPGRYOFKCNULNK-ACXQXYJUSA-N
• Gene Information: human ... NR3C2(4306)

Description

General description

Deoxycorticosterone acetate is an endogenous neurosteroid found in brain and peripheral circulation, which is produced by progesterone. It is both a mineralocorticoid and a glucocorticoid. It is used to treat adrenocortical insufficiency or Addison′s disease. Deoxycorticosterone acetate improves insulin sensitivity. It acts as a precursor to glucocorticoid corticosterone and the GABAergic neuroactive steroid (3α,5α)-3,21-dihydroxypregnan-20-one.

Application

Deoxycorticosterone acetate has been used to induce hypertensive pregnancy. It has also been used to investigate the effect of low epicatechin dosing on the cardiovascular function of deoxycorticosterone acetate (DOCA)-salt hypertensive rats.

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• ppe: Eyeshields, Gloves, type N95 (US)