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D4788

Sigma-Aldrich

2′-Deoxyadenosine 5′-triphosphate sodium salt solution

100 mM, pH 7

Synonyme(s) :

dATP

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About This Item

Numéro CE :
217-662-3
Code UNSPSC :
41106305
eCl@ss :
32160414
ID de substance PubChem :
24893898
Nomenclature NACRES :
NA.52

Pureté

≥99%

Forme

liquid

Concentration

100 mM

Couleur

colorless

pH

7

Activité étrangère

DNase, RNase, none detected

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

[Na+].Nc1ncnc2n(cnc12)[C@H]3C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)([O-])=O)O3

InChI

1S/C10H16N5O12P3.Na/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(25-7)2-24-29(20,21)27-30(22,23)26-28(17,18)19;/h3-7,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19);/q;+1/p-1/t5-,6+,7+;/m0./s1

Clé InChI

YJWCICGGRLOGEH-VWZUFWLJSA-M

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Catégories apparentées

Description générale

2′-Deoxyadenosine 5′-triphosphate (dATP) is made up of a nucleobase attached to deoxyribose and a 5′-hydroxyl on the sugar bound to a chain of three phosphate residues. dATP is used by cells for synthesis of DNA by DNA polymerases.

Application

2′-Deoxyadenosine 5′-triphosphate sodium salt solution has been used in the detection of apoptotic cells by the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) technique. It has also been used to induce oligomerization of apoptotic protease activating factor-1 (Apaf-1) to form a large heptameric complex referred to as the apoptosome or Apaf-1 procaspase-9 apoptosome complex and to study its functions as a proteolytic-based molecular timer.
2′-Deoxyadenosine 5′-triphosphate sodium salt solution is used in DNA sysnthesis reactions such as PCR, DNA sequencing and molecular cloning techniques.

Composants

T4 DNA Ligaes is supplied in a solution containing 20 mM Tris-HCl(ph 7.5), 50mM KCl, 1mM DTT, and 50% (v/v) glycerol

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Ultrasound-guided intramural inoculation of orthotopic bladder cancer xenografts: a novel high-precision approach
Jager W, et al.
Testing, 8(3), e59536-e59536 (2013)
Srinivas Malladi et al.
The EMBO journal, 28(13), 1916-1925 (2009-06-06)
During stress-induced apoptosis, the initiator caspase-9 is activated by the Apaf-1 apoptosome and must remain bound to retain significant catalytic activity. Nevertheless, in apoptotic cells the vast majority of processed caspase-9 is paradoxically observed outside the complex. We show herein
Anders Hofer et al.
Critical reviews in biochemistry and molecular biology, 47(1), 50-63 (2011-11-05)
Ribonucleotide reductase (RNR) is the only source for de novo production of the four deoxyribonucleoside triphosphate (dNTP) building blocks needed for DNA synthesis and repair. It is crucial that these dNTP pools are carefully balanced, since mutation rates increase when
Kevin N Kirouac et al.
Nucleic acids research, 41(3), 2060-2071 (2012-12-27)
Nitrated polycyclic aromatic hydrocarbons are common environmental pollutants, of which many are mutagenic and carcinogenic. 1-Nitropyrene is the most abundant nitrated polycyclic aromatic hydrocarbon, which causes DNA damage and is carcinogenic in experimental animals. Error-prone translesion synthesis of 1-nitropyrene-derived DNA
U C Halder et al.
Cell death & disease, 2, e197-e197 (2011-09-02)
During early infection, viruses activate cellular stress-response proteins such as heat-shock proteins (Hsps) to counteract apoptosis, but later on, they modulate these proteins to stimulate apoptosis for efficient viral dissemination. Hsp70 has been attributed to modulate viral entry, transcription, nuclear
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