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C4911

Chlorothiazide

Name: Chlorothiazide
Brand: SIGMA

synthetic (organic), ≥98% (HPLC), carbonic anhydrase inhibitor, powder

Synonyme(s) :

6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

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A propos de cet article

Formule empirique (notation de Hill) :

C₇H₆ClN₃O₄S₂

Numéro CAS:

58-94-6

Poids moléculaire :

295.72

NACRES:

NA.77

PubChem Substance ID:

24278150

UNSPSC Code:

12352202

EC Number:

200-404-9

MDL number:

MFCD00058576

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Propriétés

Nom du produit

Chlorothiazide, thiazide diuretic

biological source

synthetic (organic)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

mp

>300 °C

solubility

DMF: 50 mg/mL, clear, colorless to very faintly yellow

storage temp.

2-8°C

SMILES string

O=S(C1=C2C=C(Cl)C(S(N)(=O)=O)=C1)(NC=N2)=O

InChI

1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)

InChI key

JBMKAUGHUNFTOL-UHFFFAOYSA-N

Gene Information

human ... CA1(759), CA4(762), SLC12A3(6559)

Description

General description

Chlorothiazide (CTLD) is a thiazide-like diuretics and has antihypertensive effects.[1]

Application

One of the first in the thiazide class of diuretics.

Chlorothiazide has been used as a reference standard in parallel artificial membrane permeability assay (PAMPA). It has also been used to test its effect on blocking pendrin activity.[2]

Biochem/physiol Actions

Chlorothiazide (CTLD) shows structural resemblance with hydrochlorothiazide by having a sulfonamide group, but exhibits a long action duration.[3] CTLD is an inhibitor of carbonic anhydrase and is more potent than hydrochlorothiazide.[3]

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Cet article	1121005	C1700000	H4759
Sigma-Aldrich C4911 Chlorothiazide	USP 1121005 Chlorothiazide	C1700000 Chlorothiazide	Sigma-Aldrich H4759 Hydrochlorothiazide
biological source synthetic (organic)	biological source -	biological source -	biological source -
assay ≥98% (HPLC)	assay -	assay -	assay -
Gene Information human ... CA1(759), CA4(762), SLC12A3(6559)	Gene Information human ... SLC12A3(6559)	Gene Information human ... SLC12A3(6559)	Gene Information human ... ALB(213), CA1(759), CA11(770), CA12(771), CA13(377677), CA14(23632), CA2(760), CA3(761), CA4(762), CA5A(763), CA6(765), CA7(766), CA8(767), CA9(768), SLC12A3(6559)
Quality Level 100	Quality Level -	Quality Level -	Quality Level 200
form powder	form -	form -	form crystalline
solubility DMF: 50 mg/mL, clear, colorless to very faintly yellow	solubility -	solubility -	solubility -

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pictograms

GHS08

signalword

Danger

hcodes

H317,H334

pcodes

P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Classe de stockage

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c