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C3630

Sigma-Aldrich

Creatine monohydrate

≥98%, suitable for cell culture

Synonyme(s) :

Creatine hydrate, Creatine, monohydrate, N-(aminoiminomethyl)-N-methyl-glycine hydrate

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About This Item

Formule empirique (notation de Hill):
C4H9N3O2 · H2O
Numéro CAS:
6020-87-7
Poids moléculaire :
149.15
Numéro Beilstein :
7942755
Numéro CE :
200-306-6
Numéro MDL:
MFCD00071582
Code UNSPSC :
12352209
ID de substance PubChem :
24892629
Nomenclature NACRES :
NA.26

product name

Creatine monohydrate, ≥98%

Pureté

≥98%

Forme

powder

Technique(s)

cell culture | mammalian: suitable

Couleur

white to off-white

Pf

292 °C

Chaîne SMILES 

O.CN(CC(O)=O)C(N)=N

InChI

1S/C4H9N3O2.H2O/c1-7(4(5)6)2-3(8)9;/h2H2,1H3,(H3,5,6)(H,8,9);1H2

Clé InChI

MEJYXFHCRXAUIL-UHFFFAOYSA-N

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Application

Creatine (Cr) and phosphocreatine (PCr) are involved with rapid ATP production primarily in skeletal muscle tissue via the action of creatine kinase(s). Creatine may be used as a supplement to study its uptake mechanism and metabolism of action.

Actions biochimiques/physiologiques

Creatine is a nitrogenous compound that acts as a high-energy reservoir for the rapid regeneration of ATP. Approximately 95% of creatine is found in skeletal muscle, primarily as phosphocreatine. Creatine can be acquired through dietary consumption or formed from L-arginine, glycine, and L-methionine in a multi-step reaction that occurs in the kidneys and liver. Creatine is then transported to muscle tissue. Creatine supplementation is used for the enhancement of sports performance, primarily by increasing muscle mass. Creatine is also being investigated as a treatment of neuromuscular diseases, where it may aid in neuroprotection and by improving the cellular bioenergetic state.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Sigma-Aldrich

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Taurine suitable for cell culture, meets USP testing specifications

Sigma-Aldrich

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Phosphocreatine disodium salt hydrate ≥97%

Sigma-Aldrich

P7936

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Creatinine-(methyl-d3) 98 atom % D

Sigma-Aldrich

485446

Creatinine-(methyl-d3)

Clare E Turner et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(4), 1773-1780 (2015-01-30)
Impairment or interruption of oxygen supply compromises brain function and plays a role in neurological and neurodegenerative conditions. Creatine is a naturally occurring compound involved in the buffering, transport, and regulation of cellular energy, with the potential to replenish cellular
Domenic A LaRosa et al.
Pediatric research, 80(6), 852-860 (2016-07-29)
Maternal antenatal creatine supplementation protects the brain, kidney, and diaphragm against the effects of birth asphyxia in the spiny mouse. In this study, we examined creatine's potential to prevent damage to axial skeletal muscles. Pregnant spiny mice were fed a
Ignazio Maggio et al.
Scientific reports, 6, 37051-37051 (2016-11-16)
Mutations disrupting the reading frame of the ~2.4 Mb dystrophin-encoding DMD gene cause a fatal X-linked muscle-wasting disorder called Duchenne muscular dystrophy (DMD). Genome editing based on paired RNA-guided nucleases (RGNs) from CRISPR/Cas9 systems has been proposed for permanently repairing faulty
Yohei Tomita et al.
Diabetologia, 64(1), 70-82 (2020-10-26)
Proliferative diabetic retinopathy (PDR) with retinal neovascularisation (NV) is a leading cause of vision loss. This study identified a set of metabolites that were altered in the vitreous humour of PDR patients compared with non-diabetic control participants. We corroborated changes
Francis L Pazini et al.
Molecular neurobiology, 53(10), 6818-6834 (2015-12-15)
Ketamine has emerged as a novel strategy to treat refractory depression, producing rapid remission, but elicits some side effects that limit its use. In an attempt to investigate a safer compound that may afford an antidepressant effect similar to ketamine
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