C3167
Corticotropin Releasing Factor sheep
≥95% (HPLC)
Synonyme(s) :
CRF, CRH
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About This Item
Formule empirique (notation de Hill):
C205H339N59O63S
Numéro CAS:
Poids moléculaire :
4670.31
Numéro MDL:
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.32
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Amino Acid Sequence
Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Thr-Lys-Ala-Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-NH2
Actions biochimiques/physiologiques
CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.
Autres remarques
Lyophilized from 0.1% TFA in H2O
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
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Susan K Wood et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 304(11), R940-R950 (2013-04-05)
Barrington's nucleus, in the pons, regulates micturition through spinal projections to preganglionic parasympathetic neurons. The stress neuropeptide CRF is prominent in these projections and has an inhibitory influence. Social stress in rats causes urinary retention and abnormal urodynamics resembling those
L O E Ebbesson et al.
Journal of neuroendocrinology, 23(8), 733-741 (2011-05-20)
Salmon parr-smolt transformation (smoltification) is a mid-life transitional stage between life in freshwater and seawater that entails a wide range of neural, endocrine and physiological modifications. In salmon, the neuroendocrine corticotropin-releasing factor (CRF) system regulates pituitary adrenocorticotrophic hormone and thyrotrophin
Cun Li et al.
Endocrinology, 154(7), 2365-2373 (2013-04-30)
Intrauterine growth restriction (IUGR) is an important fetal developmental problem resulting from 2 broad causes: maternal undernutrition and/or decreased fetal nutrient delivery to the fetus via placental insufficiency. IUGR is often accompanied by up-regulation of the hypothalamo-pituitary-adrenal axis (HPAA). Sheep
Joan M Vaughan et al.
Endocrinology, 154(4), 1553-1564 (2013-03-16)
Mouse (m) and human (h) urocortin 2 (Ucn 2) were identified by molecular cloning strategies and the primary sequence of their mature forms postulated by analogy to closely related members of the corticotropin-releasing factor (CRF) neuropeptide family. Because of the
Xiao-Dong Wang et al.
Nature neuroscience, 16(6), 706-713 (2013-05-07)
Stress impairs cognition via corticotropin-releasing hormone receptor 1 (CRHR1), but the molecular link between abnormal CRHR1 signaling and stress-induced cognitive impairments remains unclear. We investigated whether the cell adhesion molecule nectin-3 is required for the effects of CRHR1 on cognition
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