B1427

H-89 dihydrochloride hydrate

≥98% (HPLC), powder, PKA inhibitor

• Synonyme(s) : N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide dihydrochloride
• Formule empirique (notation de Hill): C₂₀H₂₀BrN₃O₂S · 2HCl · xH₂O
• Numéro CAS: 130964-39-5
• Poids moléculaire : 519.28 (anhydrous basis)
• Numéro MDL: MFCD11045926
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278256
• Nomenclature NACRES : NA.77

Propriétés

• product name: H-89 dihydrochloride hydrate, ≥98% (HPLC), powder
• Source biologique: synthetic (organic)
• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: off-white
• Solubilité: DMSO: 10 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: O.Cl.Cl.Brc1ccc(\C=C\CNCCNS(=O)(=O)c2cccc3cnccc23)cc1
• InChI: 1S/C20H20BrN3O2S.2ClH.H2O/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20;;;/h1-10,12,15,22,24H,11,13-14H2;2*1H;1H2/b3-2+;;;
• Clé InChI: GKFFJFGBWAGAFD-HZBIHQSRSA-N
• Informations sur le gène: human ... PRKAR1A(5573) , PRKAR1AP(5574) , PRKAR1B(5575) , PRKAR2A(5576) , PRKAR2B(5577)

Description

Application

H-89 dihydrochloride hydrate has been used in the inhibition of protein kinase A in Leydig cells, primary calvarial osteoblasts (pOBs), rat granulosa cell line (LH-15 cells) and human umbilical vein endothelial cells (HUVECs).

Actions biochimiques/physiologiques

H-89 dihydrochloride hydrate is a selective inhibitor of protein kinase A (PKA). It also inhibits potassium (K⁺) current in rat myocytes. It mediates Na⁺ transport by interacting with α subunits of epithelial Na⁺ channel (ENaC).

Selective, potent inhibitor of cAMP-dependent protein kinase.

Caractéristiques et avantages

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the PKA & PKG and PKB/Akt pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)