A9451
Aristolochic acid I sodium salt
powder, ≥97%
Synonyme(s) :
Aristolochic acid sodium salt
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A propos de cet article
Formule empirique (notation de Hill) :
C17H10NNaO7
Numéro CAS:
Poids moléculaire :
363.25
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
EC Number:
233-463-4
MDL number:
Assay:
≥97%
Form:
powder
Solubility:
H2O: 50 mg/mL
Service technique
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assay
≥97%
form
powder
solubility
H2O: 50 mg/mL
SMILES string
[Na+].COc1cccc2c1cc([N+]([O-])=O)c3c(cc4OCOc4c23)C([O-])=O
InChI
1S/C17H11NO7.Na/c1-23-12-4-2-3-8-9(12)5-11(18(21)22)14-10(17(19)20)6-13-16(15(8)14)25-7-24-13;/h2-6H,7H2,1H3,(H,19,20);/q;+1/p-1
InChI key
BQVOPWJSBBMGBR-UHFFFAOYSA-M
Biochem/physiol Actions
Component of some Chinese herbal medicines, and responsible for their nephrotoxicity. Prodrug activated by reduction of the nitro group to an amine, which forms cytotoxic DNA adducts.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Carc. 2
Classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Huan Lu et al.
Theranostics, 10(10), 4323-4333 (2020-04-16)
Rationale: Dietary exposure to aristolochic acids and similar compounds (collectively, AA) is a significant risk factor for nephropathy and subsequent upper tract urothelial carcinoma (UTUC). East Asian populations, who have a high prevalence of UTUC, have an unusual genome-wide AA-induced
Marika Manolopoulou et al.
American journal of physiology. Renal physiology, 316(5), F847-F855 (2019-02-14)
Flow cytometry studies on injured kidney tubules are complicated by the low yield of nucleated single cells. Furthermore, cell-specific responses such as cell cycle dynamics in vivo have conventionally relied on indirect immunohistochemistry and proximal tubule markers that may be
Khai Gene Leong et al.
Toxins, 13(10) (2021-10-23)
The plant-derived toxin, aristolochic acid (AA), is the cause of Chinese Herb Nephropathy and Balkan Nephropathy. Ingestion of high dose AA induces acute kidney injury, while chronic low dose ingestion leads to progressive kidney disease. Ingested AA is taken up
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| A9451-50MG | 04061833616499 |
| A9451-250MG | 04061833616482 |