A9106

ADP-ribosylcyclase

1000-3000 units/mg protein

• Synonyme(s) : Adenosine diphosphoribose cyclase from Aplysia californica
• Numéro CAS: 135622-82-1
• UNSPSC Code: 12352204
• NACRES: NA.54
• MDL number: MFCD00212894
• Specific activity: 1000-3000 units/mg protein
• Assay: ≥80 μ protein/vial (BCA)
• Biological source: (Aplysia californica)
• Concentration: ≤10% (BCA method)

Propriétés

• biological source: (Aplysia californica)
• Quality Segment: 200
• assay: ≥80 μ protein/vial (BCA)
• form: lyophilized powder
• specific activity: 1000-3000 units/mg protein
• composition: Protein, ≤10%
• packaging: vial of ≥80 μg protein
• storage condition: dry at room temperature
• concentration: ≤10% (BCA method)
• suitability: suitable for enzyme test
• application(s): genomic analysis
• storage temp.: −20°C

Description

Application

ADP-ribosylcyclase is a Ca²⁺ signaling second messenger. It may be used to study calcium signaling and has been used to research morphine antinociception and tolerance .

Biochem/physiol Actions

ADP-ribosylcyclase is an intracellular calcium regulator that cyclizes NAD into cADPR. It is thought that the majority of ADP-ribosylcyclase activity in the brain is linked to CD38. Nicotinamide is a known inhibitor of CD38 ADP-ribosylcyclase activity .

Physical form

Lyophilized powder containing trehalose, potassium phosphate and dithiothreitol

Other Notes

One unit will produce 1 μmole of cyclic ADP ribose from β-NAD⁺ in 5 minutes at pH 7.0 and 25°C.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mot-clé: Danger
• Codes de danger: H334
• Mentions de précaution: P261 - P284 - P501
• Hazard Classifications: Resp. Sens. 1
• Classe de stockage: 11 - Combustible Solids
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• EPI (équipement de protection individuelle): Eyeshields, Gloves, type N95 (US)