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A2987

Sigma-Aldrich

Atractylenolide III

≥98% (HPLC)

Synonyme(s) :

8β-Hydroxyasterolide, Codonolactone

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About This Item

Formule empirique (notation de Hill):
C15H20O3
Numéro CAS:
73030-71-4
Poids moléculaire :
248.32
Numéro MDL:
MFCD00238543
Code UNSPSC :
12352200
ID de substance PubChem :
329770808
Nomenclature NACRES :
NA.25

Source biologique

Atractylodes macrocephala Koidz.

Pureté

≥98% (HPLC)

Forme

powder or crystals

Couleur

white to off-white

Solubilité

methanol: 1 mg/mL, clear, colorless

Application(s)

metabolomics
vitamins, nutraceuticals, and natural products

Température de stockage

2-8°C

Chaîne SMILES 

CC1=C2C[C@H]3C(=C)CCC[C@]3(C)C[C@]2(O)OC1=O

InChI

1S/C15H20O3/c1-9-5-4-6-14(3)8-15(17)12(7-11(9)14)10(2)13(16)18-15/h11,17H,1,4-8H2,2-3H3/t11-,14+,15-/m0/s1

Clé InChI

FBMORZZOJSDNRQ-GLQYFDAESA-N

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Description générale

Atractylenolide III is a biologically active sesquiterpene compound, extracted from the roots of Atractylodes macrocephala Koidzumi.

Application

Atractylenolide III has been used to examine its effects on the energy metabolism in the skeletal muscles of mouse.
Atractylenolide III, a sesquiterpenoid, is a phytochemical that may be used to study its anti-inflammatory and anti-angiogenesis activities. Atractylenolide III may be used and studied as an inhibitor of aromatases and inducer of apoptosis. Atractylenolide III may be used to study its sonic hedgehog pathway dependent mechanism of action as an inducer of chondrogenic differentiation. Atractylenolide III may be used as a reference material in assays to detect its presence in plant root extracts and biological milieu such as plasma.

Actions biochimiques/physiologiques

Atractylenolide III has been shown to possess anti-inflammatory effects and also offers gastroprotection. It also shows acaricidal properties and hence has the potential to be used as an agent for the control of dust mites. Atractylenolide III is capable of regulating the secretion and expression of Interleukin-6, thereby mediating the immune response caused by mast cells.
Atractylenolide III possesses anti-inflammatory and anticancer properties.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Kun-Teng Wang et al.
The Journal of pharmacy and pharmacology, 62(3), 381-388 (2010-05-22)
The rhizome of Atractylodes ovata De Candolle is popularly used in traditional Chinese medicine to treat gastrointestinal diseases. However, the major gastroprotective compounds of A. ovata have not been identified. This study reports on the principal gastro- protective component of
Hyun-Kyung Kim et al.
Journal of agricultural and food chemistry, 55(15), 6027-6031 (2007-06-28)
The acaricidal activity of materials derived from rhizome of Atractylodes ovata (Atractylodes macrocephala) toward adult Dermatophagoides farinae and Dermatophagoides pteronyssinus was examined using fabric-circle residual contact and vapor-phase toxicity bioassays. Results were compared with those of the currently used acaricides:
Yue Qiu et al.
Evidence-based complementary and alternative medicine : eCAM, 2019, 1392020-1392020 (2020-01-18)
Gastroesophageal reflux disease (GERDs) is a common chronic digestive system disease, in which the symptoms of reflux esophagitis (RE) seriously affect the quality of life. We aimed to study the therapeutic effect of Zhujie Hewei granules (ZHG) on reflux esophagitis
Yuanyuan Fu et al.
Journal of pharmaceutical and biomedical analysis, 174, 595-607 (2019-07-02)
Banxia-Baizhu-Tianma decoction (BBTD) is a compound formulae of traditional Chinese medicine (TCM), which has been clinically used for treatments of neural vertigo, hypertension and epilepsy with a long history. In this study, with an ultra-fast liquid chromatography coupled with quadrupole
Xican Li et al.
Biological & pharmaceutical bulletin, 35(8), 1328-1335 (2012-08-07)
Molecules that enhance chondrogenic differentiation in mesenchymal stem cells (MSCs) were identified and isolated using an in vitro Gli reporter gene assay in MSCs incorporating a Sonic Hedgehog (Shh) target. Atractylenolide III, which promoted Gli1-mediated transcriptional activity, was isolated from
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