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A0409

Sigma-Aldrich

Anti-α1-Antitrypsin antibody produced in rabbit

IgG fraction of antiserum

Synonyme(s) :

Alpha 1 Antitrypsin Antibody, Alpha 1 Antitrypsin Antibody - Anti-α1-Antitrypsin antibody produced in rabbit, anti-A1AT

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About This Item

Numéro MDL:
MFCD00162392
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.46
Le tarif et la disponibilité ne sont pas disponibles actuellement.

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

IgG fraction of antiserum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Poids mol.

antigen ~50 kDa

Espèces réactives

human

Conditionnement

vial of 2 mL lyophilized antiserum

Technique(s)

immunoelectrophoresis: suitable
indirect ELISA: 1:30,000-1:60,000

Numéro d'accès UniProt

P01009

Température de stockage

2-8°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... SERPINA1(5265)

Description générale

α-1-antitrypsin belongs to the serpin family and is a strong serine protease inhibitor. Its pivotal role is to protect lower respiratory tract against proteolytic destruction by human leukocyte elastase. Mutation in AAT gene will reduce the serum concentration of α-1-antitrypsin and hence increase the risk of emphysema. Anti-α1-antitrypsin antibody (diluted 1:9000) can be used as a capture antibody for determination of transgene expressions levels. It can also be used in immunoelectrophoresis. Rabbit anti-α1-antitrypsin antibody reacts specifically with α1-antitrypsin of human.

Immunogène

Purified human α-1-antitrypsin

Application

Anti-α1-antitrypsin antibody (diluted 1: 1000) can be used in ELISA. It can also be used for probing immunoblots to identify A1AT. Additionally, it can be used in Ouchterlony double diffusion.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Rabbit anti-α1-antitrypsin antibody can also be used in immunoelectrophoretic techniques.

Forme physique

Lyophilized from 0.01 M phosphate buffered saline, pH 7.2.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
0000307837
0000307837
0000219666
0000219666
0000154612

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Pedro E Cruz et al.
Laboratory investigation; a journal of technical methods and pathology, 87(9), 893-902 (2007-06-27)
alpha-1 Antitrypsin (AAT) deficiency is one of the most common genetic diseases in North America, with a carrier frequency of approximately 4% in the US population. Homozygosity for the most common mutation (Glu342Lys, PI(*)Z) leads to the synthesis of a
Michael J Iannotti et al.
ACS chemical biology, 14(3), 497-505 (2019-01-31)
Nearly one-third of the encoded proteome is comprised of secretory proteins that enable communication between cells and organ systems, playing a ubiquitous role in human health and disease. High-throughput detection of secreted proteins would enhance efforts to identify therapies for
Mingming Gao et al.
Scientific reports, 9(1), 13427-13427 (2019-09-19)
Obesity and associated metabolic comorbidities represent a growing public health problem. In this study, we demonstrate the use of a newly created fusion gene of exendin-4 and α1-antitrypsin to control obesity and obesity-associated metabolic disorders including insulin resistance, fatty liver
James K Stoller et al.
American journal of respiratory and critical care medicine, 185(3), 246-259 (2011-10-01)
α(1)-Antitrypsin (AAT) deficiency is an underrecognized genetic condition that affects approximately 1 in 2,000 to 1 in 5,000 individuals and predisposes to liver disease and early-onset emphysema. AAT is mainly produced in the liver and functions to protect the lung
Joerg Schuettrumpf et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 13(1), 88-97 (2005-10-19)
Identifying factors that influence gene transfer efficacy is critical for a successful gene-based clinical study. Here we demonstrate that in vivo AAV-2-mediated gene transfer is efficiently inhibited by unfractionated heparin, but not by a heparin preparation containing mainly low-molecular-weight forms
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