82669

1-Pyrenebutyric hydrazide

suitable for fluorescence, ≥97.0% (T)

• Synonyme(s) : 4-(1-Pyrenyl)butyric hydrazide
• Formule empirique (notation de Hill) : C₂₀H₁₈N₂O
• Numéro CAS: 55486-13-0
• Poids moléculaire : 302.37
• NACRES: NA.32
• PubChem Substance ID: 329769260
• UNSPSC Code: 12352125
• MDL number: MFCD00467260

Propriétés

• Quality Segment: 100
• assay: ≥97.0% (T)
• form: solid
• mp: 167-171 °C
• suitability: suitable for fluorescence
• SMILES string: NNC(=O)CCCc1ccc2ccc3cccc4ccc1c2c34
• InChI: 1S/C20H18N2O/c21-22-18(23)6-2-3-13-7-8-16-10-9-14-4-1-5-15-11-12-17(13)20(16)19(14)15/h1,4-5,7-12H,2-3,6,21H2,(H,22,23)
• InChI key: SOPPDVMSOKMZOC-UHFFFAOYSA-N

Description

General description

1-Pyrenebutyric hydrazide (PBH) finds biological/medical applications in the detection, labeling, and quantification of biological carbonyl compounds including aldehydes and/or ketones and carboxylic acids. It is also industrially used in chemo-sensor materials, lubricants, etc.

Application

1-Pyrenebutyric hydrazide may be used as a fluorescence derivatization reagent in the following:

• Determination of succinylacetone (SA) in urine samples of hepatorenal tyrosinemia patients using high-pressure liquid chromatography with fluorescence detection (HPLC-FLD).
• Determination of glutaric and 3-hydroxyglutaric acids in urine of glutaric acidemia type I patients using HPLC technique with intramolecular excimer-forming fluorescence derivatization.

Other Notes

Fluorescent labeling reagent for carbonyl compounds, e.g. cyclobutanones formed on food irradiation; Labeling of other compounds

Informations sur la sécurité

• pictograms: GHS07
• signalword: Warning
• hcodes: H302 + H312 + H332,H315,H319,H335
• pcodes: P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Classe de stockage: 13 - Non Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves