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Sigma-Aldrich

Lincomycine hydrochloride

96.0-102.0% (HPLC)

Synonyme(s) :

Lincocin hydrochloride, Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-α-D-galactooctopyranoside hydrochloride

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About This Item

Formule empirique (notation de Hill):
C18H34N2O6S · HCl
Numéro CAS:
859-18-7
Poids moléculaire :
443.00
Numéro Beilstein :
4171650
Numéro CE :
212-726-7
Numéro MDL:
MFCD00083647
Code UNSPSC :
51284507
ID de substance PubChem :
329759714
Nomenclature NACRES :
NA.85

Niveau de qualité

200

Pureté

96.0-102.0% (HPLC)

Forme

powder or crystals

Impuretés

≤5% water

Couleur

white to off-white

Solubilité

H2O: 50 mg/mL, clear, colorless to faintly yellow

Spectre d'activité de l'antibiotique

Gram-positive bacteria

Mode d’action

protein synthesis | interferes

Température de stockage

2-8°C

Chaîne SMILES 

Cl.CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@@H](C)O)[C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O

InChI

1S/C18H34N2O6S.ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9-,10-,11+,12-,13+,14-,15-,16-,18-;/m1./s1

Clé InChI

POUMFISTNHIPTI-BOMBIWCESA-N

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Catégories apparentées

Description générale

Chemical structure: macrolide

Actions biochimiques/physiologiques

Mode of action: Lincomycin inhibits bacterial protein synthesis by forming cross-links within the peptidyl transferase loop region of the 23S rRNA.†

Antimicrobial spectrum: Lincomycin hydrochloride is effective against gram-positive bacteria.

Notes préparatoires

This product is soluble in water at 50 mg/mL, yielding a clear, colorless solution.

Autres remarques

Keep container tightly closed in a dry and well-ventilated place.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Nerissa L Fisher et al.
PloS one, 15(12), e0244252-e0244252 (2020-12-29)
Marine phytoplankton, and in particular diatoms, are responsible for almost half of all primary production on Earth. Diatom species thrive from polar to tropical waters and across light environments that are highly complex to relatively benign, and so have evolved
J Slots et al.
Antimicrobial agents and chemotherapy, 18(1), 9-12 (1980-07-01)
The agar dilution technique was used for determination of the antibiotic susceptibilities of 57 oral isolates and 2 nonoral isolates of Actinobacillus actinomycetemcomitans. Tetracycline, minocycline, and chloramphenicol inhibited more than 96% of the strains tested at a concentration of less
S Takebe et al.
Journal of clinical microbiology, 20(5), 869-873 (1984-11-01)
When Ureaplasma urealyticum T-960 was inoculated into normal human urine (10(8) viable cells per ml of urine), a white precipitate formed, with an increase in pH of the infected urine. This precipitate was identified as a mixture of struvite and
H Malke et al.
Antimicrobial agents and chemotherapy, 19(1), 91-100 (1981-01-01)
The phenomenon of zonal resistance to lincomycin, which is characteristic of most clinical isolates with lincomycin resistance in Streptococcus pyogenes, has been studied. These strains grow within a defined concentration range of lincomycin (approximately 60 to 200 microgram/ml), or at
Ulrich Schreiber et al.
Photosynthesis research, 114(3), 165-177 (2013-02-15)
A new type of multi-color PAM chlorophyll fluorometer (Schreiber et al. 2012) was applied for measurements of photodamage to photosystem II (PS II) in optically thin suspensions of Chlorella (200 μg Chl l(-1)) in the presence of 1 mM lincomycin.
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Inhibition of Protein Synthesis by Antibiotics

Antibiotics targeting bacterial ribosomes disrupt protein synthesis, a key process in bacterial growth inhibition.

Inhibition of Protein Synthesis by Antibiotics

Antibiotics targeting bacterial ribosomes disrupt protein synthesis, a key process in bacterial growth inhibition.

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