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Y0001025

Benazepril hydrochloride

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

(3S)-3-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid hydrochloride

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About This Item

Formule empirique (notation de Hill):
C24H28N2O5 · HCl
Numéro CAS:
86541-74-4
Poids moléculaire :
460.95
Numéro MDL:
MFCD00895734
Code UNSPSC :
41116107
ID de substance PubChem :
329831225
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

benazepril

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

Cl[H].CCOC(=O)[C@H](CCc1ccccc1)N[C@H]2CCc3ccccc3N(CC(O)=O)C2=O

InChI

1S/C24H28N2O5.ClH/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28;/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28);1H/t19-,20-;/m0./s1

Clé InChI

VPSRQEHTHIMDQM-FKLPMGAJSA-N

Informations sur le gène

human ... ACE(1636)

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Benazepril hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Benazepril is a long-acting angiotensin converting enzyme (ACE) inhibitor.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Y0001038

Benazepril for system suitability, European Pharmacopoeia (EP) Reference Standard

Y0001026

Acide (3R)-3-[[(1R)-1-(éthoxycarbonyl)-3-phénylpropyl]amino]-2,3,4,5-tétrahydro-2-oxo-1H-1-benzazépine-1-acétique hydrochloride, European Pharmacopoeia (EP) Reference Standard

1048685

Benazepril Related Compound G, United States Pharmacopeia (USP) Reference Standard

1048674

Benazepril Related Compound F, United States Pharmacopeia (USP) Reference Standard

1048620

Composé A apparenté au bénazépril, United States Pharmacopeia (USP) Reference Standard

1048619

Benazepril hydrochloride, United States Pharmacopeia (USP) Reference Standard

1048652

Benazepril Related Compound D, United States Pharmacopeia (USP) Reference Standard

1048663

Benazepril Related Compound E, United States Pharmacopeia (USP) Reference Standard

1048641

Benazepril Related Compound C, United States Pharmacopeia (USP) Reference Standard

1048630

Benazepril Related Compound B, United States Pharmacopeia (USP) Reference Standard

PHR1912

Benazepril hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2422

Benazepril Related Compound E, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2423

Benazepril Related Compound F, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2922

Benazepril Related Compound D, certified reference material, pharmaceutical secondary standard

PHR2930

Benazepril Related Compound G, certified reference material, pharmaceutical secondary standard

PHR8937

Benazepril Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material

PHR8936

Acide (3R)-3-[[(1R)-1-(éthoxycarbonyl)-3-phénylpropyl]amino]-2,3,4,5-tétrahydro-2-oxo-1H-1-benzazépine-1-acétique hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

Pictogrammes

Health hazard
GHS08

Mention d'avertissement

Warning

Mentions de danger

H361fd

Classification des risques

Repr. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Application of LC and HPTLC-densitometry for the simultaneous determination of benazepril hydrochloride and hydrochlorothiazide.
El-Gindy A, et al.
Journal of Pharmaceutical and Biomedical Analysis, 25(2), 171-179 (2001)
Bjoern B Burckhardt et al.
Journal of pharmaceutical and biomedical analysis, 96, 118-126 (2014-04-18)
Although serum and plasma are the biological fluids of choice for pharmacokinetic determination of drugs in adults, it is desirable to elucidate noninvasive methods which can be used for investigations in vulnerable groups such as children. If the drug properties
Simultaneous determination of benazepril hydrochloride and hydrochlorothiazide in tablets by second-order derivative spectrophotometry.
Panderi E I.
Journal of Pharmaceutical and Biomedical Analysis, 21(2), 257-265 (1999)
Bjoern B Burckhardt et al.
Biomedical chromatography : BMC, 28(12), 1679-1691 (2014-05-03)
The benefit-risk ratio of combined blocking by the direct renin inhibitor aliskiren and an angiotensin-converting enzyme inhibitor (e.g. enalapril) on the renin-angiotensin-aldosterone system is discussed. No method was available for simultaneous determination of both drugs in urine. A novel sensitive
Haruka Nishimuta et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(9), 1522-1531 (2014-07-06)
Hydrolysis plays an important role in metabolic activation of prodrugs. In the current study, species and in vitro system differences in hepatic and extrahepatic hydrolysis were investigated for 11 prodrugs. Ten prodrugs in the data set are predominantly hydrolyzed by

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