E2503000

Etomidate

European Pharmacopoeia (EP) Reference Standard

• Synonyme(s) : (R)-1-(α-Methylbenzyl)imidazole-5-carboxylic acid ethyl ester, Amidate, R16659
• Formule empirique (notation de Hill) : C₁₄H₁₆N₂O₂
• Numéro CAS: 33125-97-2
• Poids moléculaire : 244.29
• NACRES: NA.24
• PubChem Substance ID: 329799031
• UNSPSC Code: 41116107
• MDL number: MFCD00869295
• eCl@ss: 25140904

Propriétés

• grade: pharmaceutical primary standard
• API family: etomidate
• manufacturer/tradename: EDQM
• application(s): pharmaceutical; pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: CCOC(=O)c1cncn1[C@H](C)c2ccccc2
• InChI: 1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1
• InChI key: NPUKDXXFDDZOKR-LLVKDONJSA-N
• Gene Information: human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879) ;

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Etomidate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Etomidate is a general anesthetic; potentiates GABA_A transmission

Etomidate is a general anesthetic; potentiates GABAA transmission. The possible neuroprotective effect of etomidate against streptozotocin-induced (STZ-induced) hyperglycaemia were investigated in the rat brain and spinal cord. Etomidate treatment demonstrated neuroprotective effect on the neuronal tissue against the diabetic oxidative damage

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Informations sur la sécurité

• Pictogrammes: GHS07,GHS09
• Mot-clé: Warning
• Codes de danger: H302,H410
• Mentions de précaution: P273 - P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Classe de stockage: 11 - Combustible Solids
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable