76899

Témozolomide

VETRANAL^®, analytical standard

• Synonyme(s) : 3,4-Dihydro-3-méthyl-4-oxoimidazo[5,1-d]-1,2,3,5-tétrazine-8-carboxamide, 3-Méthyl-4-oxo-8-imidazolo[5,1-d][1,2,3,5]tétrazinecarboxamide, 4-Méthyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triène-9-carboxamide, 8-Carbamoyl-3-méthylimidazo[5,1-d]-1,2,3,5-tétrazin-4(3H)-one, NSC 362856
• Formule empirique (notation de Hill) : C₆H₆N₆O₂
• Numéro CAS: 85622-93-1
• Poids moléculaire : 194.15
• NACRES: NA.24
• PubChem Substance ID: 329767423
• UNSPSC Code: 41116107
• MDL number: MFCD00866492

Propriétés

• grade: analytical standard
• Quality Segment: 100
• product line: VETRANAL^®
• assay: ≥99.0% (HPLC)
• shelf life: limited shelf life, expiry date on the label
• technique(s): HPLC: suitable, gas chromatography (GC): suitable
• ign. residue: ≤0.2%
• loss: ≤0.5% loss on drying
• application(s): forensics and toxicology; pharmaceutical (small molecule); veterinary
• format: neat
• storage temp.: 2-8°C
• SMILES string: CN1N=Nc2c(ncn2C1=O)C(N)=O
• InChI: 1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
• InChI key: BPEGJWRSRHCHSN-UHFFFAOYSA-N

Description

General description

Temozolomide (TMZ) is an alkylating agent of the imidazotetrazine derivatives that shows broad-spectrum antitumor activity against murine tumors.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

TMZ may be used as a reference standard for the analysis of temozolomide in serum and brain tumor samples by micellar electrokinetic capillary chromatography (MEKC), in aqueous solutions by liquid chromatography-electrospray-tandem mass spectrometry (LC-ESI-MS/MS), in active pharmaceutical ingredients (APIs) by high performance liquid chromatography (HPLC) with MS/MS and in pharmaceutical dosage form by HPLC equipped with photodiode array (PDA) detector.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302,H315,H319,H335,H340,H350,H360FD
• pcodes: P201 - P202 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges