MABE320

Anti-c-ErbB2/c-Neu (Ab-5) Antibody, clone TA-1

clone TA-1, from mouse

• Synonyme(s) : Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, CD340
• UNSPSC Code: 12352203
• NACRES: NA.41
• eCl@ss: 32160702
• Conjugate: unconjugated
• Clone: TA-1, monoclonal
• Application: FACS, IF, IP, WB
• Citations: 2

Propriétés

• biological source: mouse
• Quality Segment: 100
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: TA-1, monoclonal
• species reactivity: human
• technique(s): flow cytometry: suitable, immunofluorescence: suitable, immunoprecipitation (IP): suitable, western blot: suitable
• isotype: IgG1κ
• NCBI accession no.: NP_001005862
• UniProt accession no.: P04626
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... ERBB2(2064)

Description

General description

Poids théorique (calculé) : 138 kDa

The ErbB2 (HER2, c-Neu, ErbB2, c-erbB2, or HER2/neu) protein is member of the human epidermal growth factor receptor (HER) family. It is a receptor tyrosine kinase containing an intracellular kinase domain and an extracellular ligand domain, although no endogenous ligand has yet been found. γ Coupling with ErbB3 activates the PI3K pathway, whereas coupling with any of these three receptors can induce the MAPK pathway. ErbB2 signaling promotes cell proliferation and inhibits apoptosis. ErbB2 is overexpressed in various cancers and may play a role in the development and metastasis of gliomas, and ovarian, breast, lung, and gastric cancer.

Immunogen

Cells overexpressing human c-ErbB2/c-Neu

Épitope : domaine extracellulaire

Application

&

Analyse par cytométrie en flux : A representative lot from an independent laboratory detected c-ErbB2/c-Neu in HER-2 expressing SK-BR-3 cells (Montgomery, R. B., et al. (2005).

A representative lot from an independent laboratory detected c-ErbB2/c-Neu in HER-2 expressing SK-BR-3 cells (Montgomery, R. B., et al. (2005).

A representative lot from an independent laboratory precipitated c-ErbB2/c-Neu in IP (McKenzie, S. J., et al. (1989).

A representative lot from an independent laboratory detected c-ErbB2/c-Neu in IF (McKenzie, S. J., et al. (1989). 4(5):543-548.).

Sous-domaine de recherche
Cycle cellulaire, réplication et réparation de l'ADN

This Anti-c-ErbB2/c-Neu (Ab-5) Antibody, clone TA-1 is validated for use in Western Blotting, Flow Cytometry, Immunoprecipitation, Immunofluorescence for the detection of c-ErbB2/c-Neu (Ab-5).

Biochem/physiol Actions

This antibody recognizes the extracellular domain of ErbB2/c-Neu.

Physical form

κ

Format : Produit purifié

Produit purifié sur protéine G

Preparation Note

Stable entre 2 et 8 °C pendant 1 an à compter de la date de réception.

Analysis Note

µ

Other Notes

Concentration : pour connaître la concentration spécifique du lot, voir le certificat d'analyse.

Remplace le(s) produit(s) suivant(s) : 04-1127

Disclaimer

Sauf indication contraire dans notre catalogue ou toute autre documentation associée au(x) produit(s), nos produits sont uniquement destinés à la recherche et ne sauraient être utilisés à d'autres fins, ce qui inclut, sans s'y limiter, les utilisations commerciales non autorisées, les utilisations diagnostiques in vitro, les utilisations thérapeutiques ex vivo ou in vivo, ou tout type de consommation ou d'application chez l'être humain ou chez l'animal.

Informations sur la sécurité

• Classe de stockage: 12 - Non Combustible Liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable