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Key Documents

AB2256

Sigma-Aldrich

Anti-GABA B Receptor R1 Antibody

serum, from guinea pig

Synonyme(s) :

GABA-B receptor, GABA-B receptor 1, GABAB, subunit 1c, gamma-aminobutyric acid (GABA) B receptor 1, gamma-aminobutyric acid B receptor 1, seven transmembrane helix receptor

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

guinea pig

Niveau de qualité

Forme d'anticorps

serum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Espèces réactives

mouse, human, rat

Technique(s)

immunohistochemistry: suitable
western blot: suitable

Numéro d'accès NCBI

Numéro d'accès UniProt

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

mouse ... Gabbr1(54393)

Description générale

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.

Spécificité

Cat. # AB2256 recognizes GABA B Receptor R1 (GABA B R1)
Reactivity with other species has not been determined.

Immunogène

Epitope: C-Terminus
interaction w/ ATF4
Recombinant peptide (aa 972-991: PSEPPDRLSCDGSRVHLLYK)

Application

Detect GABA B Receptor R1 using this Anti-GABA B Receptor R1 Antibody validated for use in WB, IH.
Immunohistochemistry: Working dilution of 1:3,000 in free floating mouse brain tissue.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors

Qualité

Western Blotting: 1:1,000 dilution from a previous lot detected GABA B R1 on 10µg of rat brain lysate.

Description de la cible

~100-105 kDa

Forme physique

GST-Depleted Sera with 0.05% NaN3.

Stockage et stabilité

Stable for 1 year at -20ºC from date of receipt.

Remarque sur l'analyse

Control
Rat brain lysates

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Ji-Yong Kang et al.
The Journal of biological chemistry, 292(16), 6621-6632 (2017-02-19)
The behavioral and anatomical deficits seen in fragile X syndrome (FXS) are widely believed to result from imbalances in the relative strengths of excitatory and inhibitory neurotransmission. Although modified neuronal excitability is thought to be of significance, the contribution that
Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen.
Lancaster, E; Lai, M; Peng, X; Hughes, E; Constantinescu, R; Raizer, J; Friedman et al.
Lancet Neurology null
Matthew T Valley et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(37), 14660-14665 (2013-09-13)
Neuronal regeneration occurs naturally in a few restricted mammalian brain regions, but its functional significance remains debated. Here we search for unique features in the synaptic outputs made by adult-born granule cell interneurons in the mouse olfactory bulb using optogenetic
Shigenori Inagaki et al.
Cell reports, 31(13), 107814-107814 (2020-07-02)
Sensory information is selectively or non-selectively enhanced and inhibited in the brain, but it remains unclear whether and how this occurs at the most peripheral level. Using in vivo calcium imaging of mouse olfactory bulb and olfactory epithelium in wild-type and
Camille Mazo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(32), 8289-8304 (2016-08-12)
Sensory perception emerges from the confluence of sensory inputs that encode the composition of external environment and top-down feedback that conveys information from higher brain centers. In olfaction, sensory input activity is initially processed in the olfactory bulb (OB), serving

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