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Key Documents

AB1954

Sigma-Aldrich

Anti-Fibronectin Antibody

Chemicon®, from rabbit

Synonyme(s) :

Cold-insoluble globulin, fibronectin 1, migration stimulating factor, migration-stimulating factor

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Produit purifié par

affinity chromatography

Espèces réactives

mouse, rat

Conditionnement

antibody small pack of 25 μL

Fabricant/nom de marque

Chemicon®

Technique(s)

ELISA: suitable
western blot: suitable

Numéro d'accès UniProt

Conditions d'expédition

ambient

Température de stockage

2-8°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... FN1(2335)
mouse ... Fn1(14268)

Description générale

Fibronectin (FN) is involved in many cellular processes, including tissue repair, embryogenesis, blood clotting, and cell migration/adhesion. Fibronectin exists in two main forms: 1) as an insoluble glycoprotein dimer that serves as a linker in the ECM (extracellular matrix), and; 2) as a soluble disulphide linked dimer found in the plasma (plasma FN). The plasma form is synthesized by hepatocytes, and the ECM form is made by fibroblasts, chondrocytes, endothelial cells, macrophages, as well as certain epithelial cells.

Spécificité

Other species have not been tested.
The antibody reacts with the 262 kDa fibronectin protein.

Immunogène

Purified rat plasma fibronectin.

Application

Anti-Fibronectin Antibody detects level of Fibronectin & has been published & validated for use in ELISA & WB.
Research Category
Cell Structure
Research Sub Category
ECM Proteins

Qualité

Routinely evaluated by Western Blot on normal rat serum.

Western Blot Analysis:
0.05 μg/mL - 1 μg/mL antibody detected fibronectin in 15 μL of normal rat serum.

Description de la cible

262 kDa

Forme physique

Antigen Affinity Purified
Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Remarque sur l'analyse

Control
Western Blot: Normal rat serum

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informations légales

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Cláudia Silva Souza et al.
Experimental biology and medicine (Maywood, N.J.), 244(9), 758-769 (2019-05-02)
To date, no studies have been found evaluating the effects of physical exercise on renal function and structure changes in ovariectomized rats with type 1 diabetes. Therefore, this work emerges with an important tool for strengthening and expanding innovative research
Ina V Martin et al.
American journal of physiology. Renal physiology, 314(1), F35-F46 (2017-09-15)
Complement factor C5a has two known receptors, C5aR, which mediates proinflammatory effects, and C5L2, a potential C5a decoy receptor. We previously identified C5a/C5aR signaling as a potent profibrotic pathway in the kidney. Here we tested for the first time the
Rugmani Padmanabhan Iyer et al.
American journal of physiology. Heart and circulatory physiology, 311(3), H822-H836 (2016-08-16)
The purpose of this study was to evaluate the effect of sham surgery in a minimally invasive surgical model of permanent coronary artery occlusion used to generate myocardial infarction (MI) in mice. Adult male C57BL/6J mice (3-6 mo old) were
Ruiting Wang et al.
Cell biology international, 46(3), 381-390 (2021-12-23)
Mitochondrial homeostasis plays essential role for the proper functioning of the kidney. NADH-ubiquinone oxidoreductase core subunit V1 (NDUFV1) is an enzyme in the complex I of electron transport chain (ETC) in mitochondria. In the present study, we examined the effects
Jialin Li et al.
Pharmaceutical biology, 60(1), 1690-1700 (2022-09-09)
Kirenol possesses anti-inflammatory, antifibrotic and anti-arthritic effects. However, its reno-protective effects against diabetic nephropathy (DN) have not been evaluated. This study explores the reno-protective effects of kirenol against DN and clarifies the potential mechanisms. The mesangial cells were treated with

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