8.51005
DSC
≥99.0% (HPLC), for peptide synthesis, Novabiochem®
Synonyme(s) :
DSC, N,N′-Disuccinimidyl carbonate, Di-(N-Succinimidyl)carbonate
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A propos de cet article
Formule empirique (notation de Hill) :
C9H8N2O7
Numéro CAS:
Poids moléculaire :
256.17
UNSPSC Code:
12352108
EC Index Number:
277-730-3
NACRES:
NA.22
MDL number:
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Laissez-nous vous aiderNom du produit
DSC, N,N′-Disuccinimidyl carbonate Novabiochem®
Quality Segment
product line
Novabiochem®
assay
≥99.0% (HPLC)
form
powder
reaction suitability
reaction type: Coupling Reactions
manufacturer/tradename
Novabiochem®
mp
188-191 °C
application(s)
peptide synthesis
storage temp.
2-8°C
SMILES string
N2(C(=O)CCC2=O)OC(=O)ON1C(=O)CCC1=O
InChI
1S/C9H8N2O7/c12-5-1-2-6(13)10(5)17-9(16)18-11-7(14)3-4-8(11)15/h1-4H2
InChI key
PFYXSUNOLOJMDX-UHFFFAOYSA-N
General description
A convenient reagent for the synthesis of N-succinimidyl esters of N-protected amino acids [1,2,3,4].
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references
[1] H. Ogura, et al. (1979) Tetrahedron Lett., 20, 4745.
[2] H. Ogura, et al. (1981) Tetrahedron Lett., 22, 4817.
[3] K. Takeda, et al. (1982) Synth. Commun., 12, 213.
[4] K. Takeda, et al. (1983) TetrahedronLett., 24, 4569.
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references
[1] H. Ogura, et al. (1979) Tetrahedron Lett., 20, 4745.
[2] H. Ogura, et al. (1981) Tetrahedron Lett., 22, 4817.
[3] K. Takeda, et al. (1982) Synth. Commun., 12, 213.
[4] K. Takeda, et al. (1983) TetrahedronLett., 24, 4569.
Application
- Utilization in solid-phase peptide synthesis: Discusses the role of N,N′-disuccinimidyl carbonate in solid-phase peptide synthesis, providing insights into its effectiveness in enhancing coupling reactions (Meschaninova et al., 2019).
- Surface functionalization of polymeric materials: This article explores the application of N,N′-disuccinimidyl carbonate in the surface functionalization of polymers to improve their biocompatibility and interaction with biological molecules (Yakufu et al., 2020).
- Development of affinity chromatography technologies: Details the use of N,N′-disuccinimidyl carbonate in the development of novel affinity chromatography approaches for protein purification (Hinamoto et al., 2023).
- Enhancement of polymer properties: Investigates how N,N′-disuccinimidyl carbonate can be used to modify polymer surfaces to enhance their properties, such as increased hydrophilicity and reactivity (Swar et al., 2020).
Analysis Note
Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Water (K. F.): ≤ 0.50 %
Identity (IR): passes test
Appearance of substance (visual): powder
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Water (K. F.): ≤ 0.50 %
Identity (IR): passes test
Other Notes
Replaces: 01-62-0006
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
hcodes
Hazard Classifications
Acute Tox. 4 Oral
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