691400

Zebularine

≥95% (HPLC), cytidine deaminase inhibitor, solid

• Synonyme(s) : Zebularine, 1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside
• Formule empirique (notation de Hill) : C₉H₁₂N₂O₅
• Numéro CAS: 3690-10-6
• Poids moléculaire : 228.20
• UNSPSC Code: 12352200
• NACRES: NA.32
• MDL number: MFCD04973699
• Assay: ≥95% (HPLC)
• Form: solid
• Storage condition: OK to freeze

Propriétés

• Nom du produit: Zebularine, A cell-permeable chemically stable cytidine analog that displays antitumor properties.
• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: off-white
• solubility: DMSO: 5 mg/mL, methanol: 5 mg/mL
• shipped in: wet ice
• storage temp.: 2-8°C
• SMILES string: N2(C=CC=NC2=O)C1OC(C(C1O)O)CO
• InChI: 1S/C9H12N2O5/c12-4-5-6(13)7(14)8(16-5)11-3-1-2-10-9(11)15/h1-3,5-8,12-14H,4H2
• InChI key: RPQZTTQVRYEKCR-UHFFFAOYSA-N

Description

General description

A cell-permeable chemically stable cytidine analog that displays antitumor properties. Acts as transition state analog inhibitor of cytidine deaminase by binding at the active site as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.

A chemically stable, cytidine analog that displays anti-tumor properties. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Cytidine deaminase

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.





From Catalog:

Desc. Field- added "cell-permeable"

Slight warming may be required to achieve complete solubilization.

Other Notes

Cheng, J.C., et al. 2004. Cancer Cell6, 151.
Cheng, J.C., et al. 2003. J. Natl. Cancer Inst.95, 399.
Zhou, L., et al. 2002. J. Mol. Biol.321, 591.
Barchi, J.J., Jr., et al. 1992. J. Org. Chem.57, 536.
Frick, L., et al. 1989. Biochemistry28, 9423.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable