573099

Stattic

≥95% (HPLC), STAT3 inhibitor, solid

• Synonyme(s) : STAT3 Inhibitor V, Stattic, 6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound
• Formule empirique (notation de Hill) : C₈H₅NO₄S
• Numéro CAS: 19983-44-9
• Poids moléculaire : 211.19
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00173799
• Assay: ≥95% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Propriétés

• Nom du produit: STAT3 Inhibitor V, Stattic, STAT3 Inhibitor V, Stattic, CAS 19983-44-9, is a cell-permeable inhibitor of STAT3 cellular function that targets the STAT3-SH2 domain and prevents its association with upstream Kinases.
• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: pale yellow
• solubility: DMSO: 10 mg/mL, ethanol: 5 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: [S]1(=O)(=O)c2c(ccc(c2)[N+](=O)[O-])C=C1
• InChI: 1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H
• InChI key: ZRRGOUHITGRLBA-UHFFFAOYSA-N

Description

General description

A cell-permeable vinyl-sulfone compound that acts as an inhibitor of STAT3 cellular function by targeting the STAT3-SH2 domain and preventing its association with upstream kinases. The effect of Stattic towards STAT family members is temperature-dependent and appears to be highly STAT3-selective at 37°C. Shown to inhibit cellular phosphorylation of STAT3 at Tyr⁷⁰⁵ with little effect towards STAT1 phosphorylation at Tyr⁷⁰¹ (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
STAT3

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Note: The use of freshly opened DMSO strongly recommended; the thiol impurities present in DMSO will modify the molecule. Highly recommended to reconstitute just before each use.

Other Notes

Schust, J., et al. 2006. Chem. Biol.13, 1235.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Informations sur la sécurité

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H335
• pcodes: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable