539149

Proteasome Substrate VI, Fluorogenic

A fluorogenic substrate probe useful for assaying trypsin-like activity of proteasome.

• Synonyme(s) : Proteasome Substrate VI, Fluorogenic, Z-ARR-AMC, 2HCl
• Formule empirique (notation de Hill): C₃₃H₄₄N₁₀O₇ · 2HCl
• Numéro CAS: 90468-18-1
• Poids moléculaire : 765.69
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white to off-white
• Solubilité: DMSO: 200 mg/mL; 80% acetic acid: 50 mg/mL; methanol: soluble
• Fluorescence: λ_ex ~380 nm; λ_em ~460 nm
• Conditions d'expédition: ambient
• Température de stockage: −20°C

Description

Description générale

A fluorogenic substrate for assaying trypsin-like activity of proteasome. Also serves as a substrate for cathepsin B. Excitation max: 360-380 nm; emission max.: 430-460 nm.

A fluorogenic substrate probe useful for assaying trypsin-like activity of proteasome. Also reported to be a specific substrate for cathepsin B.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
Proteasome

Product does not compete with ATP.

Reversible: no

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Séquence

Z-Ala-Arg-Arg-AMC

Forme physique

Supplied as hydrochloride salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C

Autres remarques

Geier, E., et al. 1999. Science283, 978.
Dick, T.P., et al. 1998. J. Biol. Chem. 273, 25637.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable