520222

PPACK dihydrochloride

≥80% (HPLC), solid, thrombin inhibitor, Calbiochem^®

• Synonyme(s) : PPACK, Dihydrochloride
• Numéro CAS: 82188-90-7
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥80% (HPLC)
• Form: solid
• Storage condition: OK to freeze, desiccated, protect from light

Propriétés

• Nom du produit: PPACK, Dihydrochloride, PPACK, Dihydrochloride is an extremely potent and selective irreversible inhibitor of thrombin (K_obs/[I] = 10⁷M⁻¹S⁻¹). Reacts with thrombin in a 1:1 stoichiometry.
• description: Merck USA index - 14, 7699
• Quality Segment: 100
• assay: ≥80% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated, protect from light
• color: white
• solubility: water: 100 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: ClCC(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)Cc2ccccc2)CCCN=C(N)N.Cl.Cl

Description

General description

Extremely potent and selective irreversible inhibitor of thrombin (K_obs/[I] = 10⁷M^-1S^-1). Reacts with thrombin in a 1:1 stoichiometry. Can also be used to inhibit tissue plasminogen activator, Factor VIIa, and Factor XIa. Also available as a 25 mM solution in H₂O (Cat. No. 508773 ).

Biochem/physiol Actions

Cell permeable: no

Kobs/[I] = 107 M⁻¹ sec⁻¹ as inhibitor of thrombin

Primary Target
Thrombin

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions (pH <4) are stable for up to 4 months at -20°C. Rapidly decomposes at an alkaline pH.

Other Notes

H-D-Phe-Pro-Arg-chloromethylketone, 2HCl

Rosado, J. A., et al. 2002. J. Biol. Chem.277, 42157.
Odake S., et al. 1995. J. Enzyme Inhib.9, 17.
Arni, R.K., et al. 1993. Biochemistry 32, 4727.
Yamashita, T., et al. 1993. Thromb. Res. 69, 93.
Schmaier, A.H., et al. 1992. Thromb. Res.67, 479.
Collen, D., et al. 1982. J. Lab. Clin. Med.99, 76.
Kettner, C., and Shaw, E. 1981. Methods Enzymol.80, 826.
Kettner, C., and Shaw, E. 1979. Thromb. Res.14, 969.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable