475956

c-Myc Inhibitor

≥95% (sum of two isomers, HPLC), c-Myc-Max interaction inhibitor, solid

• Synonyme(s) : c-Myc Inhibitor, 10058-F4, ( Z,E)-5-(4-Ethylbenzylidine)-2-thioxothiazolidin-4-one, 10058-F4, (Z,E)-5-(4-Ethylbenzylidine)-2-thioxothiazolidin-4-one
• Formule empirique (notation de Hill) : C₁₂H₁₁NOS₂
• Numéro CAS: 403811-55-2
• Poids moléculaire : 249.35
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00758517
• Assay: ≥95% (sum of two isomers, HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Propriétés

• Nom du produit: c-Myc Inhibitor, The c-Myc Inhibitor, also referenced under CAS 403811-55-2, controls the biological activity of c-Myc.
• Quality Segment: 100
• assay: ≥95% (sum of two isomers, HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: yellow
• solubility: DMSO: 200 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: S1\C(=C\c2ccc(cc2)CC)\C(=O)NC1=S
• InChI: 1S/C12H11NOS2/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)/b10-7+
• InChI key: SVXDHPADAXBMFB-JXMROGBWSA-N

Description

General description

A cell-permeable thiazolidinone compound that specifically inhibits the c-Myc-Max interaction, thereby preventing the transactivation of c-Myc target gene expression. Shown to inhibit tumor cell growth in a c-Myc-dependent manner both in vitro and in vivo (64 μM using c-Myc transfected Rat1a fibroblasts).

A cell-permeable, thiazolidinone compound that specifically inhibits c-Myc-Max interaction, thereby preventing the transactivation of c-Myc targeted gene expression. Shown to inhibit tumor cell growth in a c-Myc-dependent manner both in vitro and in vivo (Effective concentration: 64 µM using c-Myc-transfected Rat1a fibroblasts).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
c-Myc

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Yin, X., et al. 2003. Oncogene22, 6151.

Legal Information

Sold under license of U.S. Patent 7,026,343.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

Informations sur la sécurité

• Pictogrammes: GHS07
• Mot-clé: Warning
• Codes de danger: H317,H319
• Mentions de précaution: P261 - P264 - P272 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Sens. 1
• Classe de stockage: 11 - Combustible Solids
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable