444264

MMP Inhibitor III

The MMP Inhibitor III, also referenced under CAS 927827-98-3, controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Synonyme(s) : MMP Inhibitor III
• Formule empirique (notation de Hill) : C₁₉H₂₉N₃O₄
• Numéro CAS: 927827-98-3
• Poids moléculaire : 363.45
• MDL number: MFCD00001382
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥90% (TLC)
• Form: lyophilized solid
• Storage condition: OK to freeze, desiccated

Propriétés

• Quality Segment: 100
• assay: ≥90% (TLC)
• form: lyophilized solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated
• color: off-white
• solubility: DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Description

General description

A homophenylalanine-hydroxamic acid based broad-spectrum cell-permeable, reversible inhibitor of matrix metalloproteinases (supplied as a racemic mixture). Inhibits MMP-1 (IC₅₀ = 7.4 nM), MMP-2 (IC₅₀ = 2.3 nM), MMP-3 (IC₅₀ = 135 nM), MMP-7 (IC₅₀ = 10-100 nM), and MMP-13 (IC₅₀ = 1-10 nM).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
MMP-1

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 7.4 nM, 2.3 nM, 135 nM, 10-100 nM, 1-10 nM, against MMP-1, MMP-2, MMP-3, MMP-7, and MMP-13, respectively

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months (-20°C).

Other Notes

Covington, M.D., et al. 2006, Am. J. Physiol. Renal. Physiol.290, F43.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable