444225

MMP-3 Inhibitor II

The MMP-3 Inhibitor II, also referenced under CAS 161314-17-6, controls the biological activity of MMP-3. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Synonyme(s) : MMP-3 Inhibitor II, N-Isobutyl-N-(4-methoxyphenylsulfonyl)-glycylhydroxamic Acid, NNGH
• Formule empirique (notation de Hill) : C₁₃H₂₀N₂O₅S
• Numéro CAS: 161314-17-6
• Poids moléculaire : 316.37
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD02179370
• Assay: ≥98% (TLC)
• Form: solid
• Storage condition: OK to freeze

Propriétés

• Quality Segment: 100
• assay: ≥98% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: DMSO: 30 mg/mL, ethanol: 8 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• SMILES string: [S](=O)(=O)(N(CC(C)C)CC(=O)NO)c1ccc(cc1)OC
• InChI: 1S/C13H20N2O5S/c1-10(2)8-15(9-13(16)14-17)21(18,19)12-6-4-11(20-3)5-7-12/h4-7,10,17H,8-9H2,1-3H3,(H,14,16)
• InChI key: JIRXORZYIXSWOB-UHFFFAOYSA-N

Description

General description

A cell-permeable, potent inhibitor of human MMP-3 (stromelysin; K_i = 130 nM).

A potent and cell-permeable inhibitor of human MMP-3 (K_i = 130 nM).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
human MMP-3

Product does not compete with ATP.

Reversible: no

Target K_i: 130 nM against human MMP-3

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Kato, N., et al. 2002. Genome Informatics13, 272.
MacPherson, L.J., et al. 1997. J. Med. Chem. 40, 2525.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable