437725

Lipoxin A₄, 15-epi

Lipoxin A₄, 15-epi, CAS 171030-11-8, is an epimeric lipoxin A4 (Cat. No. 437720) analog that is more potent and metabolically stable than LXA4.

• Synonyme(s) : Lipoxin A₄, 15-epi, LXA₄-15-epi, 15( R)-LXA₄, Aspirin-triggered LXA₄, (5 S,6 R,15 R)-5,6,15-Trihydroxy-7,9,13- trans-11- cis-eicosatetraenoic acid, LXA₄-15-epi, 15(R)-LXA₄, Aspirin-triggered LXA₄, (5S,6R,15R)-5,6,15-Trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid
• Formule empirique (notation de Hill): C₂₀H₃₂O₅
• Numéro CAS: 171030-11-8
• Poids moléculaire : 352.47
• Code UNSPSC : 12352211
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: liquid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic); protect from light
• Conditions d'expédition: wet ice
• Température de stockage: −70°C
• InChI: 1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4+,7-5+,13-9+,14-10+
• Clé InChI: IXAQOQZEOGMIQS-CRSXNMAESA-N

Description

Description générale

A epimeric lipoxin A₄ (Cat. No. 437720) analog that is more potent and metabolically stable than LXA₄. Exhibits anti-inflammatory properties and serves as a "stop signal" to excessive leukocyte trafficking/infiltration. Blocks TNF-α-induced IL-8 release in human enterocyte. It is also an important modulator of the many pharmacological actions caused by aspirin.

An epimeric lipoxin A₄ (Cat. No. 437720) analog that is more potent and metabolically stable than LXA₄. Exhibits anti-inflammatory properties and serves as a "stop signal" to excessive leukocyte trafficking/infiltration. Reported to block TNF-α-induced IL-8 release in human enterocytes. Also reported to be an important modulator of the pharmacological actions of aspirin.



Caution! Product contains volatile liquid; keep cold at all times.

Caution! Product contains volatile liquid. Keep product cold at all times.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
Exhibits anti-inflammatory properties

Product does not compete with ATP.

Reversible: no

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Flammable (J)

Forme physique

In Ethanol.

Reconstitution

Following initial thaw aliquot and freeze (-70°C).

Autres remarques

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Wallace, J.L., and Fiorucci, S. 2003. Trends Pharmacol. Sci.24, 323.
Filep, J.G., et al. 2002. Adv. Exp. Med. Biol.507, 223.
Titos, E., et al. 1999. Am. J. Physiol.277, C870.
Gronert, K., et al. 1998. J. Exp. Med.187, 1285.
Maddox, J.F., et al. 1997. J. Biol. Chem.272, 6972.
Claria, J., et al. 1996. Mol. Med.2, 583.
Claria, J., and Serhan, C.N. 1995. Proc. Natl. Acad. Sci. USA92, 9475.
Serhan, C.N., et al. 1995. Biochemistry34, 14609.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS02,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H225,H319
• Conseils de prudence: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Flam. Liq. 2
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 55.4 °F
• Point d'éclair (°C): 13 °C