345701

Gambogic Acid, Garcinia hanburyi

A cell-permeable caspase activator and an apoptosis inducer that was originally isolated from gamboge resin for its antimicrobial properties.

• Synonyme(s) : Gambogic Acid, Garcinia hanburyi, Guttic Acid, β-Guttiferin
• Formule empirique (notation de Hill): C₃₈H₄₄O₈
• Numéro CAS: 2752-65-0
• Poids moléculaire : 628.75
• Code UNSPSC : 12352106
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (TLC)
• Forme: amorphous solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: orange
• Solubilité: DMSO: 10 mg/mL; ethanol: soluble
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C38H44O8/c1-20(2)10-9-15-36(8)16-14-24-29(39)28-30(40)26-18-23-19-27-35(6,7)46-37(33(23)41,17-13-22(5)34(42)43)38(26,27)45-32(28)25(31(24)44-36)12-11-21(3)4/h10-11,13-14,16,18,23,27,39H,9,12,15,17,19H2,1-8H3,(H,42,43)/b22-13-/t23?,27?,36-,37?,38-/m1/s1
• Clé InChI: GEZHEQNLKAOMCA-PLUQQRNKSA-N

Description

Description générale

A cell-permeable caspase activator and an apoptosis inducer that was originally isolated from gamboge resin for its antimicrobial properties. Shown to inhibit the growth of HeLa and HEL cells minimal inhibitory concentrations (MIC = 12.5 µg/ml).

A cell-permeable, anti-microbial xanthone orignally isolated from the gamboge resin of Garcinia hanburyi. Acts as a caspase activator and apoptosis inducer. Shown to inhibit the growth of HeLa and HEL cells (MIC = 12.5 µg/ml). Reported to block telomerase activity in SMMC-7721 cells. Shown to induce tyrosine kinase phosphatase SHP-1 and suppress Stat3 activation.

Actions biochimiques/physiologiques

Cell permeable: yes

MIC = 12.5 µg/ml in inhibiting the growth of HeLa and HEL cells

Primary Target
Caspase activator and an apoptosis inducer

Product does not compete with ATP.

Reversible: no

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

Autres remarques

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Prasad, S., et al. 2011. Cancer Prev. Res.4, 1084.
Guo, Q.L., et al. 2004. Acta Pharmacol. Sin.25, 769.
Asano, J., et al. 1996. Phytochemistry41, 815.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301,H315,H319,H335
• Conseils de prudence: P261 - P264 - P270 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable