236020

Etomoxir

≥98% (HPLC), solid, CPT-1 inhibitor

• Synonyme(s) : Etomoxir, R(+)-2-[6-(4-Chlorophenoxy)hexyl]-oxirane-2-carboxylic acid sodium salt hydrate
• Formule empirique (notation de Hill) : C₁₅H₁₈ClO₄ · Na
• Numéro CAS: 828934-41-4
• Poids moléculaire : 320.74
• MDL number: MFCD07787411
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Propriétés

• Nom du produit: Etomoxir, A cell-permeable, irreversible, and stereospecific compound that is shown to inhibit carnitine palmitoyltransferase (CPT)-1 and DGAT activity in the mitochondria of rat heart H9c2 myoblastic cells.
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: white
• solubility: DMSO: 50 mg/mL (or water)
• shipped in: wet ice
• storage temp.: 2-8°C
• SMILES string: [Na+].Clc1ccc(cc1)OCCCCCC[C@]2(OC2)C(=O)[O-]
• InChI: 1S/C15H19ClO4.Na/c16-12-5-7-13(8-6-12)19-10-4-2-1-3-9-15(11-20-15)14(17)18;/h5-8H,1-4,9-11H2,(H,17,18);/q;+1/p-1/t15-;/m1./s1
• InChI key: RPACBEVZENYWOL-XFULWGLBSA-M

Description

General description

Etomoxir (ETO), an irreversible inhibitor of carnitine palmitoyltransferase I (CPT1), primarily impacts fatty acid oxidation. It is an epoxide-based medium-chain fatty acid used to study the biological effects of mitochondrial fatty acid β-oxidation. ETO shifts energy metabolism from fatty acids to glucose oxidation. Its mechanism of action involves reducing the transport of non-esterified fatty acids (NEFA) into the mitochondrial matrix, which subsequently reduces the substrate available for β-oxidation.

Application

Etomoxir has been used in:

• the evaluation of long-chain fatty acid respiration in neonatal mouse cardiomyocytes using SeaHorse instrument
• cell stimulation experiments to study its effects on fatty acid oxidation in metabolic syndrome-associated synoviocytes
• Seahorse assays to assess fatty acid oxidation in cultured cells by inhibiting carnitine palmitoyltransferase I (CPT1)

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

Informations sur la sécurité

• Pictogrammes: GHS06
• Mot-clé: Danger
• Codes de danger: H301
• Mentions de précaution: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable