233552-M

Cobra Venom Factor, Naja naja kaouthia

Cobra Venom Factor, Naja naja kaouthia, is a native cobra venom factor. Glycoprotein composed of three non-identical disulfide-bonded subunits of 68, 48, and 30 kDa.

• Synonyme(s) : Cobra Venom Anticomplementary Protein
• UNSPSC Code: 12352202
• NACRES: NA.42
• Form: liquid
• Assay: ≥95% (SDS-PAGE)

Propriétés

• Quality Segment: 100
• assay: ≥95% (SDS-PAGE)
• form: liquid
• specific activity: ≥250 units/mL
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, avoid repeated freeze/thaw cycles
• foreign activity: Phospholipase, none detected
• storage temp.: −70°C

Description

General description

Native cobra venom factor from Naja naja kaouthia. Glycoprotein composed of three non-identical disulfide-bonded subunits with M.W. of 68 kDa (α), 48 kDa (β), and 30 kDa (γ). Cobra venom factor (CVF) is a structural and functional analog of cobra, as well as mammalian C3. Thus, in the presence of Factor B, Factor D, and Mg²⁺, CVF can form a stable CVF,Bb complex that is a C3/C5 convertase enzyme; however, the CVF,Bb complex is not susceptible to regulation by Factors H and I. Four to six µg of purified CVF are equal to 1.0 unit of functional activity as measured by the method of Cochrane, et al.

Other Notes

Bogers, W.M., et al. 1993. Eur. J. Immunol.23, 433.
Fritzinger, D.C., et al. 1992. J. Immunol. 149, 3554.
Muller, B. and Muller-Ruchholtz, W. 1987. Leuk. Res.11, 461.
Vogel, C.W. and Muller-Eberhard, H.J. 1984. J. Immunol. Methods73, 203.
Cochrane, C.G., et al. 1970. J. Immunol. 105, 55.
Ballows, M. and Cochrane, C.G. 1969. J. Immunol.103, 944.

Legal Information

Not available for sale outside the United States.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

Informations sur la sécurité

• Classe de stockage: 12 - Non Combustible Liquids
• Que se passe-t-il ?: WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable