227016
CCR2 Antagonist
≥97% (racemic mixture, HPLC), solid, CCR2 antagonist, Calbiochem®
Synonyme(s) :
CCR2 Antagonist, 2-((Isopropylaminocarbonyl)amino)-N-(2-((cis-2-((4-(methylthio)benzoyl)amino)cyclohexyl)amino)-2-oxoethyl)-5-(trifluoromethyl)-benzamide, CC Chemokine Receptor 2 Antagonist
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A propos de cet article
Formule empirique (notation de Hill) :
C28H34F3N5O4S
Numéro CAS:
Poids moléculaire :
593.66
MDL number:
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥97% (racemic mixture, HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
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CCR2 Antagonist, The CCR2 Antagonist, also referenced under CAS 445479-97-0, controls the biological activity of CCR2.
Quality Segment
assay
≥97% (racemic mixture, HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white
solubility
ethanol: 6 mg/mL, DMSO: 60 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cis-diamidocyclohexyl urea compound that potently competes against MCP-1 binding to CCR2 (IC50 = 5.1 nM) and effectively inhibits MCP-1/CCR2-mediated PBMCs Ca+2 flux and chemotaxis (IC50 = 18 and 1 nM, respectively), while showing much less effect against eotaxin binding to CCR3 (37% inhibition at 10 µM). Mutageneis analysis indicates CCR2 Thr292 is critical in maintaining the high affinity antagonist binding.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Gentle warming, rapid stirring, and/or sonication may be required for complete solubilization.
Other Notes
Cherney, R.J., et al. 2008. J. Med. Chem.51, 721.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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