203895

BTS

A potent inhibitor of Ca²⁺-stimulated myosin S1 ATPase (IC₅₀ = ~ 5 µM) and reversibly blocks the gliding motility.

• Synonyme(s) : BTS, N-Benzyl- p-toluenesulphonamide, N-Benzyl-p-toluenesulphonamide
• Formule empirique (notation de Hill): C₁₄H₁₅NO₂S
• Numéro CAS: 1576-37-0
• Poids moléculaire : 261.34
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: crystalline solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white
• Solubilité: DMSO: 200 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C14H15NO2S/c1-12-7-9-14(10-8-12)18(16,17)15-11-13-5-3-2-4-6-13/h2-10,15H,11H2,1H3
• Clé InChI: WTHKAJZQYNKTCJ-UHFFFAOYSA-N

Description

Description générale

A potent inhibitor of Ca²⁺-stimulated myosin S1 ATPase (IC₅₀ = ~ 5 µM) and reversibly blocks the gliding motility. It also weakens myosin’s interaction with F-actin. Much less effective in suppressing contraction in rat myocardial or rabbit slow twitch muscle and has no effect on platelet myosin II.

An aryl sulphonamide that acts as a potent inhibitor of Ca²⁺-stimulated myosin S1 actin-stimulated ATPase activity (IC₅₀ = ~5 µM). Also blocks actin-stimulated ATPase activity with similar potency (IC₅₀ = 5 µM). Reversibly blocks gliding motility of skeletal muscle myosin (IC₅₀<2 µM). Less effective in suppressing contraction in rat myocardial and rabbit slow twitch muscle compared to skeletal muscle. Does not inhibit platelet myosin II.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
Ca²⁺-stimulated myosin S1 ATPase

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: ~5 µM against Ca2+-stimulated myosin S1 ATPase

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Autres remarques

Cheung, A., et al. 2002. Nat. Cell Biol.4, 83.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable