203291

Bisindolylmaleimide I, Hydrochloride

An enhanced water-soluble form of Bisindolylmaleimide I.

• Synonyme(s) : Bisindolylmaleimide I, Hydrochloride, 2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide, HCl
• Formule empirique (notation de Hill) : C₂₅H₂₄N₄O₂ · xHCl
• Numéro CAS: 176504-36-2
• Poids moléculaire : 412.48 (free base basis)
• UNSPSC Code: 12352111
• NACRES: NA.77
• MDL number: MFCD00236429
• Assay: ≥95% (HPLC)
• Form: solid
• Storage condition: OK to freeze

Propriétés

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: orange-red
• solubility: water: 10 mg/mL, DMSO: 20 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: Cl.N1C(=O)C(=C(C1=O)c4c5c([nH]c4)cccc5)c2c3c([n](c2)CCCN(C)C)cccc3
• InChI: 1S/C25H24N4O2.ClH/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20;/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31);1H
• InChI key: XRAMWNCMYJHGGH-UHFFFAOYSA-N

Description

General description

A reversible and ATP-competitive inhibitor of protein kinase C (K_i = 10 nM). Inhibits protein kinase A at much higher concentrations (K_i = 2 µM). An enhanced water soluble form of Bisindolylmaleimide I (Cat. No. 203290).

An enhanced water-soluble form of Bisindolylmaleimide I (Cat. No. 203290 ). A reversible and ATP-competitive inhibitor of protein kinase C (K_i = 10 nM). May inhibit protein kinase A at much higher concentrations (K_i = 2 µM).

Biochem/physiol Actions

Cell permeable: no

Primary Target
Protein kinase C

Product competes with ATP.

Reversible: yes

Target K_i: 10 nM against protein kinase C

Preparation Note

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

Other Notes

Le Panse, R., et al. 1994. Mol. Pharmacol.46, 445.
Kuchera, S., et al. 1993. Agents Actions 39, C169.
Wilkinson, S.E., et al. 1993. Biochem. J.294, 335.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable