14-520-M
Casein Kinase 1δ (aa 1-294) Protein, active, 10 µg
Active, N-terminal, GST-tagged, recombinant human CK1 delta, amino acids 1-294, for use in Kinase Assays.
Synonyme(s) :
Kinase protein
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About This Item
Code UNSPSC :
12352202
eCl@ss :
32160405
Nomenclature NACRES :
NA.32
Produits recommandés
Source biologique
human
Niveau de qualité
Produit recombinant
expressed in E. coli
Poids mol.
Mw 61 kDa
Fabricant/nom de marque
Upstate®
Technique(s)
activity assay: suitable (kinase)
Numéro d'accès NCBI
Numéro d'accès UniProt
Informations sur le gène
human ... CSNK1D(1453)
Description générale
Research area: Cell signaling
Research Category: Metabolism Research
Subcategory: Obesity
Protein Target: CK1γδ
Target Sub-Family: CK1
Casein Kinase 1δ (CK1δ ) is a serine/threonine kinase that belong to the family of casein kinase 1. The protein structure consists of anti-parallel β-sheet strands at N-terminal lobe (N-lobe) and α-helices and loop structures at the larger C-terminal lobe (C-lobe).
Research Category: Metabolism Research
Subcategory: Obesity
Protein Target: CK1γδ
Target Sub-Family: CK1
Casein Kinase 1δ (CK1δ ) is a serine/threonine kinase that belong to the family of casein kinase 1. The protein structure consists of anti-parallel β-sheet strands at N-terminal lobe (N-lobe) and α-helices and loop structures at the larger C-terminal lobe (C-lobe).
Application
Research Category
Metabolism
Metabolism
Research Sub Category
Obesity
Metabolic Disorders
Obesity
Metabolic Disorders
Actions biochimiques/physiologiques
Casein Kinase 1δ (CK1δ) is implicated in multiple cellular processes, including membrane trafficking, cytokinesis, circadian rhythm, and tumorigenesis. It interacts with critical molecules within cancer-related signaling pathways, such as Wnt/β-catenin, PI3K/AKT, and Hedgehog. Therefore, mutations or overexpression of the CK1δ coding gene can potentially contribute to the onset and progression of cancer.
Conditionnement
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-520M when ordering the 250 µg size.
Qualité
routinely evaluated by phosphorylation of KRRRALS(p)VASLPGL
Forme physique
Glutathione-agarose
Stockage et stabilité
6 months at -20°C
Autres remarques
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Informations légales
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Skin Sens. 1
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 2
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D)
Xu P, et al.
A Manual for Genetic Engineering: Advanced Bacterial Genetics, 715 (2019)
Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D)
Xu P, et al.
Gene: X, 2019-2019 (2019)
Francesca Vena et al.
Molecular cancer therapeutics, 19(8), 1623-1635 (2020-05-21)
Although gemcitabine is the cornerstone of care for pancreatic ductal adenocarcinoma (PDA), patients lack durable responses and relapse is inevitable. While the underlying mechanisms leading to gemcitabine resistance are likely to be multifactorial, there is a strong association between activating
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