119135

Adenosine A1 Receptor Agonist I, CPA

• Synonyme(s) : Adenosine A1 Receptor Agonist I, CPA
• Formule empirique (notation de Hill) : C₁₅H₂₁N₅O₄
• Numéro CAS: 41552-82-3
• Poids moléculaire : 335.36
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00036845
• Assay: ≥99% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Propriétés

• assay: ≥99% (HPLC)
• Quality Segment: 100
• form: solid
• potency: 0.8 nM K_i
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: white
• solubility: 1 M HCl: 100 mM, DMSO: 100 mM, ethanol: 25 mM
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: [n]2(c3ncnc(c3nc2)NC4CCCC4)C1O[C@@H]([C@H]([C@H]1O)O)CO
• InChI: 1S/C15H21N5O4/c21-5-9-11(22)12(23)15(24-9)20-7-18-10-13(16-6-17-14(10)20)19-8-3-1-2-4-8/h6-9,11-12,15,21-23H,1-5H2,(H,16,17,19)/t9-,11-,12-,15?/m1/s1
• InChI key: SQMWSBKSHWARHU-FJFSNTMWSA-N

Description

General description

A potent and selective agonist of adenosine A1 receptor (A1R) (K_i = 2.3 nM, 790 nM, 18.6 µM, 43nM for human A1, A2A, A2B, and A3, respectively).

Biochem/physiol Actions

Primary Target
A1

Reversible: yes

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

slight warming is required for complete solubilization in ethanol

Other Notes

Migita, H., et al. 2008. J Neurosci Res.86, 2820.
Burgdorf, C. et al. 2005. J Cardiovasc Pharmacol.45, 1.
Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 362, 382.
Mironov, S., et al. 1990. J Neurophysiol.81, 1.
Monopoli, A., et al. 1994. Arzneimittelforschung.44, 1305.
Concas, A., et al. 1993. J Pharmacol Exp Ther.267, 844.
Lohse, M. J., et al. 1988. Nauryn Schmiedebergs Arch Pharmacol.337, 687.
Coffin, V. L., et al. 1987. J Pharmacol Exp Ther.241, 76.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable