03-32-5032

MMP-2/MMP-7 Substrate, Fluorogenic

Extremely sensitive fluorogenic substrate for matrix metalloproteinases (MMPs).

• Synonyme(s) : MMP-2/MMP-7 Substrate, Fluorogenic
• Formule empirique (notation de Hill): C₄₉H₆₈N₁₄O₁₅
• Poids moléculaire : 1093.15
• Code UNSPSC : 12352209
• Nomenclature NACRES : NA.83

Propriétés

• Niveau de qualité: 200
• Pureté: ≥95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated
• Couleur: yellow
• Solubilité: 20% acetic acid: 1 mg/mL
• Fluorescence: λ_ex ~325 nm; λ_em ~393 nm
• Conditions d'expédition: ambient
• Température de stockage: −20°C

Description

Description générale

Extremely sensitive fluorogenic substrate for matrix metalloproteinases (MMPs). Suitable for assessment of total activity in crude preparations by continuous assays (k_cat/K_m = 1.7 x 10⁵ M^-1sec^-1 for MMP-7 and 6.3 x 10⁵ M^-1sec^-1 for MMP-2).

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
Fluorogenic substrate for matrix metalloproteinases (MMPs)

Product does not compete with ATP.

Reversible: no

kcat/Km = 1.7 x 105 M-1sec-1 for MMP-7 and 6.3 x 105 M⁻¹ sec⁻¹ for MMP-2

Avertissement

Toxicity: Standard Handling (A)

Séquence

MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH₂ ·TFA [Dpa = N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]

Forme physique

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Knight, C.G., et al. 1992. FEBS Lett. 296, 263.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable