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890880P

Avanti

18:0 TAP

Avanti Research™ - A Croda Brand 890880P, powder

Synonyme(s) :

1,2-stearoyl-3-trimethylammonium-propane (chloride salt)

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About This Item

Formule empirique (notation de Hill):
C42H84NO4Cl
Numéro CAS:
220609-41-6
Poids moléculaire :
702.57
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25

Forme

powder

Conditionnement

pkg of 1 × 200 mg (890880P-200mg)
pkg of 1 × 25 mg (890880P-25mg)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand 890880P

Type de lipide

cationic lipids
transfection

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

[H]C(C[N+](C)(C)C)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[Cl-]

Application

1,2-stearoyl-3-trimethylammonium-propane (18:0 TAP) might be used:
  • for the preparation of tri-loaded bilosomes (Tri-BLs) by thin film hydration technique
  • to formulate lipid nanoparticles (LNPs), for testing its efficiency of packaging mRNA into an LNP
  • to fabricate unilamellar empty liposomes
  • to prepare lipoplexes

Actions biochimiques/physiologiques

1,2-stearoyl-3-trimethylammonium-propane (18:0 TAP) is a cationic lipid used in DNA transfection.

Conditionnement

5 mL Amber Glass Screw Cap Vial (890880P-200mg)
5 mL Amber Glass Screw Cap Vial (890880P-25mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Code de la classe de stockage

11 - Combustible Solids

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Hailing Yang et al.
Drug delivery, 26(1), 820-830 (2019-08-08)
Arthritis treatment has been challenging because of low drug exposure to the articular cavity. This study was intended to develop hyaluronic acid (HA)-functionalized bilosomes for targeted delivery of tripterine (Tri), an antiphlogistic phytomedicine, to the inflamed joint via ligand-receptor interaction.
Zhiqiang Sun et al.
Biomacromolecules, 13(10), 3395-3400 (2012-09-20)
Lipid-coated DNA nanoparticles (lipoplexes) are a powerful gene delivery tool with promising therapeutic applications. The mechanism of lipoplex assembly remains poorly understood. We explored DNA packing by a cationic lipid DSTAP (distearoyl trimethylammonium-propane) using magnetic tweezers. DSTAP-induced DNA condensation occurred
Maria Jose York-Duran et al.
Biomaterials science, 7(11), 4813-4826 (2019-09-20)
While ROS display crucial functions in many physiological processes, elevated ROS levels are also related to the initiation and progression of many severe diseases such as cancer, cardiovascular conditions or neurologic disorders. Research approaches to diminish ROS levels during disease
Siddharth Patel et al.
Journal of controlled release : official journal of the Controlled Release Society, 303, 91-100 (2019-04-16)
Retinal gene therapy has had unprecedented success in generating treatments that can halt vision loss. However, immunogenic response and long-term toxicity with the use of viral vectors remain a concern. Non-viral vectors are relatively non-immunogenic, scalable platforms that have had
Yuki Takechi-Haraya et al.
Langmuir : the ACS journal of surfaces and colloids, 34(26), 7805-7812 (2018-06-06)
It has recently been recognized that the mechanical properties of lipid nanoparticles play an important role during in vitro and in vivo behaviors such as cellular uptake, blood circulation, and biodistribution. However, there have been no quantitative investigations of the
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