930571

Pomalidomide-piperidine-carboxylic acid

≥95%

• Synonyme(s) : 1-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl], 1-[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-isoindolin-5-yl]piperidine-4-carboxylic acid, 4-Piperidinecarboxylic acid
• Formule empirique (notation de Hill) : C₁₉H₁₉N₃O₆
• Numéro CAS: 2467965-70-2
• Poids moléculaire : 385.37
• UNSPSC Code: 12352100
• NACRES: NA.21
• MDL number: MFCD34570925
• Assay: ≥95%
• Form: powder

Propriétés

• ligand: pomalidomide
• Quality Segment: 100
• assay: ≥95%
• form: powder
• greener alternative product score: old score: 59; new score: 43; Find out more about DOZN™ Scoring
• sustainability: Sustainability features
• technique(s): targeted protein degradation: suitable
• functional group: carboxylic acid
• storage temp.: 2-8°C
• SMILES string: O=C(O)C1CCN(C2=CC=C3C(=O)N(C(=O)C3=C2)C4C(=O)NC(=O)CC4)CC1
• InChI: 1S/C19H19N3O6/c23-15-4-3-14(16(24)20-15)22-17(25)12-2-1-11(9-13(12)18(22)26)21-7-5-10(6-8-21)19(27)28/h1-2,9-10,14H,3-8H2,(H,27,28)(H,20,23,24)
• InChI key: LXOQUSNJOGMSJJ-UHFFFAOYSA-N

Description

General description

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Safer Solvents and Auxiliaries”, “Design for Energy Efficiency”, and “Design for Degradation”. Click here to view its DOZN scorecard.

Application

Pomalidomide-piperidine-carboxylic acid is a functionalized cereblon ligand for development of pomalidomide-based PROTACs. Allows rapid conjugation with amine linkers due to the presence of a carboxyl group via peptide coupling reactions. A basic building block for development of a protein degrader library.

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Other Notes

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Informations sur la sécurité

• Pictogrammes: GHS08
• Mot-clé: Danger
• Codes de danger: H360D
• Mentions de précaution: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3