907324

Fmoc-L-photo-proline

≥95%

• Synonyme(s) : (S)-5-(((9H-Fluoren-9-yl)methoxy)carbonyl)-1,2,5-triazaspiro[2.4]hept-1-ene-6-carboxylic acid, (S)-5-Fmoc-1,2,5-triazaspiro[2.4]hept-1-ene-6-carboxylic acid, Diazirine amino acid, Photo-Pro, Photo-crosslinking amino acid, Photoprobe building block
• Formule empirique (notation de Hill): C₂₀H₁₇N₃O₄
• Numéro CAS: 1266778-58-8
• Poids moléculaire : 363.37
• Numéro MDL: MFCD31380718
• Code UNSPSC : 12352209

Propriétés

• Pureté: ≥95%
• Forme: powder
• Capacité de réaction: reaction type: Fmoc solid-phase peptide synthesis
• Pf: 113-116 °C
• Application(s): peptide synthesis
• Groupe fonctionnel: Fmoc
• Température de stockage: −20°C

Description

Application

Fmoc-L-photo-proline is a diazirine-containing, Fmoc-protected proline amino acid and multifunctional probe building blocks. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (∼360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An unprotected version is also available as 907286.

Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)

Autres remarques

Chemical Probes Unravel an Antimicrobial Defense Response Triggered by Binding of the Human Opioid Dynorphin to a Bacterial Sensor Kinase

Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa

Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis

Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)

Informations sur la sécurité

• Pictogrammes: GHS02
• Mention d'avertissement: Danger
• Mentions de danger: H242
• Conseils de prudence: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Classification des risques: Self-react. C
• Code de la classe de stockage: 5.2 - Organic peroxides and self-reacting hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable