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901322

Sigma-Aldrich

Bis-MPA-NHBoc dendrimer

generation 4

Synonyme(s) :

Bis-MPA dendrimer, NHBoc functionalized dendrimer, PFD-G4-TMP-NH-Boc

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About This Item

Formule empirique (notation de Hill):
C615H998N48O282
Poids moléculaire :
13576.66
Code UNSPSC :
12162002
Nomenclature NACRES :
NA.23

Forme

solid

Niveau de qualité

100

Poids mol.

generation 4

Nb de groupes de surface

48

Couleur

white to off-white

Température de stockage

−20°C

Description générale

  • Polymer architecture: Dendrimer
  • Generation: 4
  • End group functionality: Boc-protected amine
  • No. surface groups: 48
  • Calculated mol. wt.: 13576.80 g/mol
  • Boc: tert-Butyloxycarbonyl
  • Bis-MPA: 2,2-Bis(hydroxymethyl)propionic acid.

Application

Bis-MPA (or 2,2-Bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrimers synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. After boc deprotection, amine-functionalized dendrimers can be readily used in EDC or DCC coupling reactions with carbonyl-containing compounds to yield highly functionalized materials for a variety of biomedical applications.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been

Articles

Dendritic Polyester Scaffolds for Drug Delivery

Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

Dendritic Polyester Scaffolds for Drug Delivery

Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

Dendritic Polyester Scaffolds for Drug Delivery

Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

Dendritic Polyester Scaffolds for Drug Delivery

Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

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