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719889

Sigma-Aldrich

Resomer® RG 502, Poly(D,L-Lactide-co-Glycolide)

lactide:glycolide 50:50, ester terminated, Mw 7,000-17,000

Synonyme(s) :

PLGA

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About This Item

Formule linéaire :
[C3H4O2]x[C2H2O2]y
Code UNSPSC :
12162002
Nomenclature NACRES :
NA.23

Forme

amorphous

Ratio alimentaire

lactide:glycolide 50:50

Poids mol.

Mw 7,000-17,000

Intervalle de dégradation

<3 months

Viscosité

0.16-0.24 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

Température de transition

Tg 42-46 °C

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Application

Resomer® RG 502 can be used to formulate a PLGA-based nano drug delivery system for the anti-inflammatory drug, 6-bromoindirubin-3′-glycerol-oxime ether (6BIGOE).

Itcan also be used to prepare control release formulations for Naloxone HCldelivery.

Caractéristiques et avantages

  • Biocompatible
  • Biodegradable
  • Can be processed into almost any shape and size
  • Tunable mechanical properties

Informations légales

Product of Evonik
RESOMER is a registered trademark of Evonik Rohm GmbH

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Teresa Musumeci et al.
International journal of pharmaceutics, 440(2), 135-140 (2012-10-20)
Melatonin, a neurohormone secreted by the pineal gland, is able to modulate intraocular pressure (IOP). The aim of this study was to generate nanoparticle (NPs) sustained release formulations that allow to extend the pre-corneal residence time of melatonin, thus prolonging
Maria Kirzhner et al.
Ophthalmology, 120(6), 1300-1304 (2013-02-13)
To compare wrapped and polymer-coated hydroxyapatite implants in children undergoing primary enucleation with no adjuvant therapies. Retrospective, interventional cohort study. All children undergoing primary enucleation without adjuvant therapies between 1999 and 2009 at a tertiary pediatric cancer hospital. Review and
Igor Jeroukhimov et al.
Journal of the American College of Surgeons, 218(1), 102-107 (2013-11-12)
Chronic pain after inguinal hernia repair occurs in 16% to 62% of patients. The underlying mechanism probably involves sensory nerve damage and abnormal healing that might be influenced by the materials chosen for the procedure. We hypothesize that nonabsorbable sutures
Patrick Vavken et al.
Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 29(1), 122-132 (2012-12-04)
The objective of this study was to assess the effect of absorbable or nonabsorbable sutures in bioenhanced anterior cruciate ligament (ACL) repair in a skeletally immature pig model on suture tunnel and growth plate healing and biomechanical outcomes. Sixteen female
Hannu Paajanen et al.
International journal of surgery (London, England), 11(1), 81-84 (2012-12-19)
Chronic pain may be a major long-term problem related to mesh material and operative trauma in inguinal hernioplasty. Lichtenstein hernioplasty was performed under local anaesthesia in 312 patients by the same surgeon and technique between 2003 and 2005. The patients
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Articles

RESOMER® - Biodegradable Polymers for Sutures, Medical Devices, Drug Delivery Systems and Tissue Engineering

Interest in utilizing biodegradable polymers for biomedical applications has grown since the 1960s.

Poly(Glycerol Sebacate) in Tissue Engineering

Synthetic aliphatic polyesters dominate resorbable biomaterials in clinical use.

Poly(Glycerol Sebacate) in Tissue Engineering

Synthetic aliphatic polyesters dominate resorbable biomaterials in clinical use.

Poly(Glycerol Sebacate) in Tissue Engineering

Synthetic aliphatic polyesters dominate resorbable biomaterials in clinical use.

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